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Invitrogen
BMPR1A Polyclonal Antibody
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FIGURE: 1 / 15
BMPR1A Antibody (38-6000) in ICC/IF
Immunofluorescent analysis of BMPR1A /CD292 was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with BMPR1A /CD292 Rabbit Polyclonal Antibody (Product # 38-6000) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conju... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
38-6000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from an internal region of the human BMPR-1A (bone morphogenetic protein receptor type 1A, Serine/threonine protein kinase receptor R5 (SKR5), activin receptor-like kinase-3 (ALK-3)), which differs from mouse and rat BMPR-1A by one nonconservative amino acid replacement.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor, type IA; member of the TGF-beta receptor superfamily; serine/threonine-protein kinase receptor R5; unnamed protein product
Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK-3; ALK3; Bmpr; BMPR-1A; BMPR-IA; CD292; SKR5
UniProt ID: (Human) P36894, (Mouse) P36895, (Rat) Q78EA7
Entrez Gene ID: (Human) 657, (Mouse) 12166, (Rat) 81507
angiogenesis
osteoblast differentiation
chondrocyte differentiation
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
atrioventricular valve development
mitral valve morphogenesis
tricuspid valve morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
endocardial cushion formation
immune response
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
dorsal/ventral pattern formation
positive regulation of gene expression
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
negative regulation of smooth muscle cell migration
cell differentiation
positive regulation of bone mineralization
BMP signaling pathway
positive regulation of transforming growth factor beta2 production
dorsal aorta morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
stem cell differentiation
regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of SMAD protein import into nucleus
ventricular septum morphogenesis
atrioventricular node cell development
pharyngeal arch artery morphogenesis
cellular response to growth factor stimulus
cellular response to BMP stimulus
positive regulation of dendrite development
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of cardiac ventricle development
positive regulation of vascular smooth muscle cell proliferation
fibrous ring of heart morphogenesis
regulation of neural crest cell differentiation
anti-Mullerian hormone signaling pathway
in utero embryonic development
mesoderm formation
somitogenesis
Mullerian duct regression
regulation of endothelial cell proliferation
positive regulation of mesenchymal cell proliferation
heart morphogenesis
cellular iron ion homeostasis
pattern specification process
ectoderm development
nervous system development
endoderm development
heart development
dorsal/ventral axis specification
anterior/posterior pattern specification
neural crest cell development
stem cell population maintenance
pituitary gland development
neural plate mediolateral regionalization
lung development
hindlimb morphogenesis
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
regulation of endothelial cell differentiation
paraxial mesoderm development
paraxial mesoderm structural organization
lateral mesoderm development
regulation of lateral mesodermal cell fate specification
mesendoderm development
developmental growth
embryonic morphogenesis
positive regulation of epithelial cell proliferation
negative regulation of neurogenesis
cartilage development
palate development
neural plate pattern specification
heart formation
regulation of neural crest cell fate specification
regulation of cellular senescence
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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