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Invitrogen
Nucleolin Monoclonal Antibody (ZN004)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
39-6400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Xenopus
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
ZN004
Immunogen
Synthetic peptide derived from the internal region of the human nucleolin protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ45706; FLJ59041; nucl antibody; unnamed protein product
Gene Aliases: B530004O11Rik; C23; D0Nds28; D1Nds28; NCL; Nsr1; Nucl
UniProt ID: (Human) P19338, (Mouse) P09405
Entrez Gene ID: (Human) 4691, (Mouse) 17975
nucleic acid binding
RNA binding
protein binding
telomeric DNA binding
PH domain binding
identical protein binding
insulin receptor substrate binding
DNA topoisomerase binding
mRNA 5'-UTR binding
single-stranded DNA binding
receptor binding
calcium ion binding
selenocysteine insertion sequence binding
rRNA primary transcript binding
histone binding
laminin binding
sequence-specific DNA binding
ErbB-4 class receptor binding
mRNA splicing, via spliceosome
angiogenesis
regulation of gene expression
negative regulation of translation
regulation of RNA metabolic process
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
endocytosis
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin receptor signaling pathway
regulation of peptidyl-tyrosine phosphorylation
cellular response to lipopolysaccharide
cellular response to epidermal growth factor stimulus
cellular response to leukemia inhibitory factor
regulation of rRNA processing
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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