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Invitrogen
Connexin 45 Polyclonal Antibody
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FIGURE: 1 / 11
Connexin 45 Antibody (40-7000) in ICC/IF
Brain structure & function 2013 -
Fig. 4 a , b IB4 staining is clearly observed within laminae I/II of the DH and makes close appositions to both Cx45-eGFP cells within laminae I/II and those in lamina III. c - e Confocal scan of representative cells (from lamina III in a ) demonstrate the density of projections surrounding the Cx45-eGFP cells. f , g A reconstructed model example in two orientations illustrating the density of projections o... View More
Product Details
40-7000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the C-terminal region of the mouse, rat, Chinese hamster, and golden hamster connexin 45 (Cx45, GJA7, gap junction alpha-7) protein
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell closely packed transmembrane channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. Connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 is designated alpha-1 gap junction protein, whereas CX32 and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43. Connexins have four transmembrane, three intracellular, and two extracellular regions. Different tissues express different connexins, though tissue specificities overlap, and a given tissue or cell can express several different connexins. Developmental regulation of at least some of the connexin genes has been found. Embryo implantation is regulated in part by temporally changing patterns of expression of connexins in the embryo and the maternal decidua.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: connexin 45; Connexin-45; Cx45; Gap junction alpha-7 protein; Gap junction gamma-1 protein; gap junction membrane channel protein alpha 7
Gene Aliases: C130009G16Rik; Cnx45; Cx45; Cxn-45; Gja-7; Gja7; Gjc1
UniProt ID: (Mouse) P28229
Entrez Gene ID: (Mouse) 14615
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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