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Invitrogen
LXR alpha Monoclonal Antibody (K8607)
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Product Details
418200
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
K8607
Immunogen
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR--alpha (2-97 aa).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
physiological saline
Contains
0.1% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody specifically recognizes LXR alpha but does not recognize human LXR beta.
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Liver X receptor alpha; LXRb; NER; NERI; NR1H2; Nuclear receptor subfamily 1 group H member 3; Oxysterols receptor LXR-alpha; unnamed protein product
Gene Aliases: LXR-a; LXRA; NR1H3; RLD-1
UniProt ID: (Human) Q13133
Entrez Gene ID: (Human) 10062
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
cholesterol binding
chromatin DNA binding
sterol response element binding
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
lipid metabolic process
hormone-mediated signaling pathway
negative regulation of macrophage derived foam cell differentiation
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol efflux
regulation of lipid storage
negative regulation of cholesterol storage
cell differentiation
intracellular receptor signaling pathway
negative regulation of lipid transport
positive regulation of cholesterol transport
response to progesterone
positive regulation of toll-like receptor 4 signaling pathway
phosphatidylcholine acyl-chain remodeling
cholesterol homeostasis
regulation of circadian rhythm
mRNA transcription from RNA polymerase II promoter
negative regulation of macrophage activation
apoptotic cell clearance
positive regulation of fatty acid biosynthetic process
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of lipid biosynthetic process
negative regulation of pinocytosis
negative regulation of inflammatory response
lipid homeostasis
sterol homeostasis
negative regulation of interferon-gamma-mediated signaling pathway
triglyceride homeostasis
cellular response to lipopolysaccharide
negative regulation of pancreatic juice secretion
negative regulation of secretion of lysosomal enzymes
negative regulation of cold-induced thermogenesis
negative regulation of response to endoplasmic reticulum stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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