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Invitrogen

Phospho-c-Abl (Tyr245) Polyclonal Antibody

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Phospho-c-Abl (Tyr245) Polyclonal Antibody

Product Details

44-250

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:250
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human, Tag

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

synthesized phosphopeptide derived from a region of human c-Abl that contains tyrosine 245
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533616

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL kinase domain; abl protein; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; ABL2; ABLL; ARG; B30; BCR-ABL1 p190; BCR/ABL e8a2 fusion; BCR/ABL variant p190 fusion protein; BCR/ABL variant-p210 fusion protein; BCR/ABL1 e1a2 fusion protein; BCR/ABL1 fusion; BCR/ABL1 fusion protein e3a1; bcr/c-abl oncogene protein; BCR::ABL1 fusion protein; c-abl oncogene 1, receptor tyrosine kinase; chimeric BCR::ABL1 protein; H1681-BCR/ABL variant p210 fusion protein; non-receptor tyrosine kinase; p190; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine kinase protein; unnamed protein product; v-abl Abelson murine leukemia viral oncogene homolog 1

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Gene Aliases: ABL; BCR-ABL; bcr/abl; c-ABL; c-ABL1; CHDSKM; JTK7; p150; v-abl

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UniProt ID: (Human) P00519

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Entrez Gene ID: (Human) 25

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Function(s)
magnesium ion binding four-way junction DNA binding bubble DNA binding phosphotyrosine binding DNA binding transcription coactivator activity actin monomer binding nicotinate-nucleotide adenylyltransferase activity protein kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein kinase C binding protein binding ATP binding enzyme activator activity kinase activity enzyme binding protein kinase binding protein domain specific binding syntaxin binding manganese ion binding neuropilin binding SH2 domain binding protein serine/threonine kinase activator activity ephrin receptor binding actin filament binding mitogen-activated protein kinase binding proline-rich region binding delta-catenin binding supercoiled DNA binding sequence-specific double-stranded DNA binding
Process(es)
mitotic cell cycle immune effector process immune response-activating cell surface receptor signaling pathway mismatch repair regulation of transcription, DNA-templated phagocytosis cellular response to DNA damage stimulus response to oxidative stress epidermal growth factor receptor signaling pathway positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway learning or memory associative learning intrinsic apoptotic signaling pathway in response to DNA damage response to xenobiotic stimulus regulation of gene expression regulation of autophagy positive regulation of endothelial cell migration actin cytoskeleton organization actin filament polymerization regulation of endocytosis regulation of cell adhesion regulation of axon extension phospholipase C-inhibiting G-protein coupled receptor signaling pathway regulation of microtubule polymerization regulation of Cdc42 protein signal transduction regulation of actin cytoskeleton organization cellular response to oxidative stress response to endoplasmic reticulum stress intracellular signal transduction platelet-derived growth factor receptor-beta signaling pathway protein modification process Fc-gamma receptor signaling pathway involved in phagocytosis neuropilin signaling pathway signal transduction in response to DNA damage positive regulation of apoptotic process positive regulation of neuron apoptotic process endothelial cell migration regulation of T cell differentiation regulation of cell differentiation positive regulation of cell adhesion positive regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter platelet-derived growth factor receptor signaling pathway ephrin receptor signaling pathway positive regulation of fibroblast proliferation negative regulation of ubiquitin-protein transferase activity myoblast proliferation positive regulation of stress fiber assembly regulation of cell cycle mitochondrial depolarization positive regulation of focal adhesion assembly cardiac muscle cell proliferation cellular response to hydrogen peroxide DNA conformation change cellular response to transforming growth factor beta stimulus response to epinephrine positive regulation of cell migration involved in sprouting angiogenesis vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynaptic specialization assembly positive regulation of phospholipase C/protein kinase C signal transduction positive regulation of dendrite development positive regulation of substrate adhesion-dependent cell spreading negative regulation of long-term synaptic potentiation cellular response to oxygen-containing compound regulation of hematopoietic stem cell differentiation positive regulation of intracellular signal transduction positive regulation of extracellular matrix organization glomerular visceral epithelial cell apoptotic process cellular response to dopamine positive regulation of establishment of T cell polarity protein localization to cytoplasmic microtubule plus-end regulation of modification of synaptic structure positive regulation of blood vessel branching negative regulation of double-strand break repair via homologous recombination regulation of cell motility positive regulation of T cell migration
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