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Invitrogen
Phospho-MEK7 (Ser271, Thr275) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-MEK7 (Ser271, Thr275) Antibody (44-478) in WB
Peptide Competition: Extracts prepared from background extracts with GST-tagged fusion protein expressing MEK7 added were resolved by SDS-PAGE on a 10% polyacrylamide gel and transferred to PVDF. Membranes were blocked with a 5% BSA-TBST buffer overnight
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
44-478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human MEK7 that contains serine 271 and threonine 275.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a new family member of MAP kinase kinases; c-Jun N-terminal kinase kinase 2; JN; JNK-activating kinase 2; MAP kinase kinase 7; MAP2K4; MAPK/ERK kinase 4; MAPK/ERK kinase 7; MAPKK 4; MEK 4; protein kinase; protein kinase homolog; SAPK kinase 1; SAPK kinase 4; SAPK/ERK kinase 1; SAPKK-1; SAPKK1; SEK1; stress-activated protein kinase kinase 4; unnamed protein product
Gene Aliases: JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPKK-4; SAPKK4
UniProt ID: (Human) O14733
Entrez Gene ID: (Human) 5609
response to osmotic stress
signal transduction
JNK cascade
response to heat
response to UV
stress-activated protein kinase signaling cascade
positive regulation of telomere maintenance
response to tumor necrosis factor
Fc-epsilon receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
stress-activated MAPK cascade
positive regulation of ERK1 and ERK2 cascade
cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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