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Invitrogen
Phospho-VAV3 (Tyr173) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-VAV3 (Tyr173) Antibody (44-488) in WB
Vav3 (pY173) phosphospecific antibody. Cos7 cells over-expressing murine Vav3 were serum starved and left untreated (1) or treated (2-5) with EGF were incubated with Vav3 (pY173) antibody following prior incubation with: no peptide (1, 2), the non-phospho immunogen (3), a generic (pY) peptide (4), or, the phosphopeptide immunogen (5). Data demonstrate antibody specificity.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
44-488
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Vav3 that contains tyrosine 173.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ40431; guanosine nucleotide exchange factor; putative signal transduction molecule; unnamed protein product; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Gene Aliases: A530094I06Rik; Idd18.1
UniProt ID: (Human) Q9UKW4, (Mouse) Q9R0C8
Entrez Gene ID: (Human) 10451, (Mouse) 57257
immune response-regulating cell surface receptor signaling pathway
vesicle fusion
cellular response to DNA damage stimulus
cell surface receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
response to xenobiotic stimulus
cell migration
lamellipodium assembly
neutrophil chemotaxis
positive regulation of B cell proliferation
intracellular signal transduction
positive regulation of cell adhesion
B cell receptor signaling pathway
positive regulation of protein kinase B signaling
platelet activation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of small GTPase mediated signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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