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          • Primary Antibodies ›
          • IR/IGF1R Antibodies

          Invitrogen

          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal Antibody

          Advanced Verification
          11 Published Figures
          9 References
          View all (8) IR/IGF1R antibodies

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          Cite Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal Antibody

          Additional Information:

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          • Antibody Testing Data (1)
          • Published Figures (11)
          • Advanced Verification (1)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 13

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          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody (44-806G) in WB

          Western Blot using IR/IGF1R (pYpYpY1158/1162/1163) Polyclonal Antibody, Rabbit {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Immunohistochemistry (IHC)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody in Western Blot (WB)
          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Antibody

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Phospho-IR/IGF1R (Tyr1158, Tyr1162, Tyr1163) Polyclonal Antibody

          Product Details

          44-806G

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 7 publications 7 publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Miscellaneous PubMed (Misc)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse

          Published species

          Bovine, Chicken, Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic phosphopeptide derived from the region of IR/IGF1R that contains tyrosines 1158, 1162 and 1163 of the human insulin receptor (IR)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Purification

          Antigen affinity chromatography

          Storage buffer

          Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533763

          Target Information

          Insulin and Insulin-like Growth Factor receptors are transmembrane tyrosine kinase receptors that play critical roles in development, cell growth and metabolism. Insulin/Insulin-like growth factor-1 binding to the extracellular domain of IR and IGFR leads to autophosphorylation of the receptor and activation of the intrinsic tyrosine kinase activity, which allows appropriate substrates to be phosphorylated. Phosphorylation sites that are unique to each receptor presumably play a key role in these signaling differences. The catalytic loops within the tyrosine kinase domains contain a three tyrosine motif corresponding to Tyr1158, 1162 and 1163 (for the IR) and Tyr1131, 1135 and 1136 (for the IGF1R). Autophosphorylation of the tyrosine sites within the activation loop proceeds in a processive manner initiating at the second tyrosine (1162 or 1135), followed by phosphorylation at tyrosines 1158 (IGF-1R tyrosine 1131), 1163 (IGF-1R tyrosine 1136), resulting in the full activation of IR and IGF1R.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: IGF-I receptor; IGF-I Receptor beta; IGF1 Receptor; IGF1 Receptor beta; IGF1R beta; insulin receptor precursor; IR; line 186; protein-tyrosine kinase (EC 2.7.1.112); type II receptor tyrosine kinase; unnamed protein product

          View more View less

          Gene Aliases: 4932439J01Rik; A330103N21Rik; CD220; CD221; D630014A15Rik; D930020L01; HHF5; hyft; IGF-1R; IGFIR; IGFR; IR; IR-A; IR-B; JTK13

          View more View less

          UniProt ID: (Human) P08069, (Human) P06213, (Mouse) Q60751, (Mouse) P15208

          View more View less

          Entrez Gene ID: (Human) 3480, (Human) 3643, (Mouse) 16001, (Mouse) 16337

          View more View less

          Function(s)
          protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor-activated receptor activity insulin receptor binding structural molecule activity protein binding insulin-like growth factor binding ATP binding insulin-like growth factor I binding identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding beta-amyloid binding insulin-like growth factor receptor binding GTP binding protein domain specific binding protein kinase activator activity insulin-like growth factor II binding cargo receptor activity macromolecular complex binding PTB domain binding G-protein alpha-subunit binding protein transporter activity protein kinase binding protein phosphatase binding lipoic acid binding 3-phosphoinositide-dependent protein kinase binding
          Process(es)
          protein phosphorylation immune response transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis brain development positive regulation of cell proliferation insulin receptor signaling pathway epidermis development organ morphogenesis negative regulation of muscle cell apoptotic process cerebellum development establishment of cell polarity male sex determination adrenal gland development positive regulation of cell migration mammary gland development exocrine pancreas development neuron projection development positive regulation of cytokinesis cellular response to insulin stimulus positive regulation of osteoblast proliferation peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of protein complex disassembly negative regulation of MAPK cascade positive regulation of MAPK cascade estrous cycle transcytosis response to ethanol positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of JNK cascade protein autophosphorylation insulin-like growth factor receptor signaling pathway positive regulation of developmental growth positive regulation of smooth muscle cell proliferation positive regulation of axon regeneration positive regulation of DNA metabolic process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling prostate gland epithelium morphogenesis cellular response to glucose stimulus cellular response to transforming growth factor beta stimulus positive regulation of steroid hormone biosynthetic process positive regulation of cell cycle process dendritic spine maintenance beta-amyloid clearance postsynaptic modulation of chemical synaptic transmission positive regulation of cold-induced thermogenesis response to L-glutamate negative regulation of hepatocyte apoptotic process negative regulation of cholangiocyte apoptotic process cellular response to beta-amyloid cellular response to insulin-like growth factor stimulus signal transduction protein kinase B signaling cellular response to oxygen-containing compound positive regulation of receptor internalization heart morphogenesis regulation of glycogen biosynthetic process regulation of transcription, DNA-templated receptor-mediated endocytosis G-protein coupled receptor signaling pathway learning memory male gonad development regulation of gene expression regulation of glucose metabolic process glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of glycolytic process regulation of embryonic development positive regulation of glucose import viral entry into host cell animal organ development system development positive regulation of cellular component organization regulation of multicellular organismal process positive regulation of respiratory burst transport across blood-brain barrier neuron projection maintenance regulation of female gonad development negative regulation of protein phosphorylation regulation of hydrogen peroxide metabolic process positive regulation of glycoprotein biosynthetic process negative regulation of gene expression peptidyl-tyrosine phosphorylation response to nutrient levels negative regulation of transporter activity response to tumor necrosis factor positive regulation of phosphorylation cellular response to growth factor stimulus negative regulation of feeding behavior
          It has to be done as per old AB suggested Products section.

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