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Invitrogen

Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody

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17 Published Figures
23 References
View all (14) PAK1/2/3 antibodies

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Phospho-PAK1/2/3 (Ser141) Polyclonal Antibody

Product Details

44-940G

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 15 publications 15 publications

Immunohistochemistry (IHC)

-
View 3 publications 3 publications

Immunohistochemistry (Frozen) (IHC (F))

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-
View 3 publications 3 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide derived from a region of human PAK2 containing serine 141. The sequence is conserved in rat and rabbit.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533801

Target Information

In mammals, there are several identified isoforms of p21-Activated Protein Kinases or PAKs: alpha-PAK (also known as PAK-1) and beta-PAK (also known as PAK-3) are mostly brain-specific, while gamma-PAK (also known as PAK-2) is expressed ubiquitously (Jakobi et al., 2003). Mutations of the gene coding for PAK-3 are associated wit X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus (Boda et al., 2004). PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death (Jakobi et al., 2003; Walter et al., 1998). Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK (Jakobi et al., 2000).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ADRB2; adriamycin resistance-associated; aPAK; BPAK; CDKN1A; CLAP; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; oligophrenin-3; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 2; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p58; PAK 1; PAK alpha; PAK beta; PAK gamma; PAK-2; PAK-3; PAK-a; PAK-B; PAK-y; protein kinase; S6/H4 kinase; STE20 homolog, yeast; unnamed protein product; yPAK

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Gene Aliases: alpha-PAK; ARA; beta-PAK; bPAK; IDDMSSD; KNO2; MRX30; MRX47; OPHN3; p65-PAK; PAK-3; PAK3beta; PAK65; PAKalpha; PAKgamma; XLID30

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UniProt ID: (Human) Q13153, (Human) Q13177, (Human) O75914

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Entrez Gene ID: (Human) 5058, (Human) 5062, (Human) 5063

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein binding collagen binding ATP binding protein kinase binding small GTPase binding identical protein binding gamma-tubulin binding protein serine kinase activity protein tyrosine kinase activator activity cadherin binding MAP kinase kinase activity
Process(es)
MAPK cascade stimulatory C-type lectin receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis cellular response to starvation dendrite development cell migration regulation of actin filament polymerization regulation of actin cytoskeleton organization intracellular signal transduction regulation of MAPK cascade ephrin receptor signaling pathway regulation of axonogenesis synapse organization dendritic spine morphogenesis regulation of actin filament organization cardiac muscle hypertrophy protein phosphorylation signal transduction adherens junction assembly negative regulation of apoptotic process protein autophosphorylation vascular endothelial growth factor receptor signaling pathway regulation of cytoskeleton organization negative regulation of stress fiber assembly bicellular tight junction assembly cellular response to transforming growth factor beta stimulus protein localization to cell-cell junction positive regulation of extrinsic apoptotic signaling pathway response to hypoxia chromatin remodeling cellular response to DNA damage stimulus positive regulation of cell proliferation positive regulation of fibroblast migration cerebellum development establishment of cell polarity actin cytoskeleton organization positive regulation of cell migration cellular response to insulin stimulus positive regulation of intracellular estrogen receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis wound healing positive regulation of axon extension positive regulation of insulin receptor signaling pathway hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of stress fiber assembly negative regulation of cell proliferation involved in contact inhibition negative regulation of cell growth involved in cardiac muscle cell development positive regulation of microtubule nucleation positive regulation of protein targeting to membrane protein localization to cytoplasmic stress granule positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration
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