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Proteintech
RAB8A Polyclonal Antibody
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Product Details
55296-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Dog,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to RAB8A.
Target Information
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cell line NK14 derived transforming oncogene; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); Oncogene c-mel; RAB8A; ras-associated protein RAB8; Ras-related protein Rab-8A; unnamed protein product
Gene Aliases: AA409338; MEL; RAB8; RAB8A
UniProt ID: (Human) P61006, (Mouse) P55258, (Rat) P35280
Entrez Gene ID: (Human) 4218, (Mouse) 17274, (Rat) 117103
transport
intracellular protein transport
vesicle docking involved in exocytosis
small GTPase mediated signal transduction
axonogenesis
metabolic process
protein secretion
protein transport
synaptic vesicle exocytosis
regulation of exocytosis
cell projection organization
Rab protein signal transduction
cellular response to insulin stimulus
regulation of protein localization
cilium assembly
regulation of long-term neuronal synaptic plasticity
Golgi vesicle fusion to target membrane
regulation of protein transport
protein localization to plasma membrane
exocytosis
autophagy
Golgi organization
regulation of autophagy
endocytic recycling
cilium morphogenesis
protein localization to cilium
neurotransmitter receptor transport, endosome to postsynaptic membrane
neurotransmitter receptor transport to postsynaptic membrane
vesicle-mediated transport in synapse
glucose homeostasis
positive regulation of glucose import
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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