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Proteintech
HOXA11 Polyclonal Antibody
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Product Details
55495-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.71 mg/mL
Amount
106.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to Human/Mouse HOXA11 and Rat Hoxa10.
Target Information
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeo box 1I; homeo box A11; Homeobox protein Hox-1.9; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11; unnamed protein product
Gene Aliases: Hox-1.9; HOX1; HOX1I; Hoxa-11; HOXA11; RUSAT1
UniProt ID: (Human) P31270, (Mouse) P31311
Entrez Gene ID: (Human) 3207, (Mouse) 15396
skeletal system development
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
chondrocyte differentiation
chondrocyte development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
single fertilization
mesodermal cell fate specification
male gonad development
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
regulation of gene expression
positive regulation of cell development
embryonic limb morphogenesis
prostate gland development
regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
response to testosterone
embryonic forelimb morphogenesis
embryonic digit morphogenesis
response to estrogen
positive regulation of transcription, DNA-templated
cell development
developmental growth
uterus development
embryonic skeletal joint morphogenesis
bone development
cartilage development involved in endochondral bone morphogenesis
positive regulation of chondrocyte development
transcription, DNA-templated
multicellular organism development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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