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Proteintech
STAT6 Monoclonal Antibody (2E5B8)
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Product Details
66717-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E5B8
Immunogen
STAT6 Fusion Protein Ag0410 (368-567 aa encoded by BC005823)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IKRCERKGT ESVTEEKCAV LFSASFTLGP GKLPIQLQAL SLPLVVIVHG NQDNNAKATI LWYNAFSEMD RVPFVVAERV PWEKMCETLN LKFMAEVGTN RGLLPEHFLF LAQKIFNDNS LSMEAFQHRS VSWSQFNKEI LLGRGFTFWQ WFDGVLDLTK RCLRSYWSDR LIIGFISKQY VTSLLLNEPD GTFLLRFSDS E (368-567 aa encoded by BC005823)
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 12S1644; IL-4 Stat; IL4 STAT; LITAF binding protein; Mutations: 16:OK; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; Signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT; unnamed protein product
Gene Aliases: D12S1644; HIES6; IL-4-STAT; STAT6; STAT6B; STAT6C
UniProt ID: (Human) P42226, (Mouse) P52633
Entrez Gene ID: (Human) 6778, (Rat) 362896, (Mouse) 20852
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein phosphatase binding
identical protein binding
sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
signal transducer activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
T-helper 1 cell lineage commitment
negative regulation of type 2 immune response
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
JAK-STAT cascade
gene expression
cytokine-mediated signaling pathway
mammary gland epithelial cell proliferation
interleukin-4-mediated signaling pathway
regulation of cell proliferation
response to peptide hormone
positive regulation of transcription from RNA polymerase II promoter
isotype switching to IgE isotypes
positive regulation of isotype switching to IgE isotypes
JAK-STAT cascade involved in growth hormone signaling pathway
mammary gland morphogenesis
regulation of mast cell proliferation
positive regulation of cold-induced thermogenesis
transcription, DNA-templated
response to cytokine
cellular response to hydrogen peroxide
cellular response to reactive nitrogen species
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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