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Invitrogen

ErbB2 (HER-2) Recombinant Rabbit Monoclonal Antibody (7H3L20)

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ErbB2 (HER-2) Recombinant Rabbit Monoclonal Antibody (7H3L20)

Product Details

701399

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5 µg/mL
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

7H3L20

Immunogen

Peptide corresponding to amino acids 33-46 of human ERBB2
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2-7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532480

Product Specific Information

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; c-erb B2/neu protein; CD antigen CD340; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene Neu; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626

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Entrez Gene ID: (Human) 2064

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Function(s)
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity
Process(es)
protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway cell proliferation Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth regulation of microtubule-based process positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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