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Invitrogen
Kindlin Recombinant Rabbit Monoclonal Antibody (7H7L9)
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FIGURE: 1 / 3
Kindlin Antibody (701830) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized A-431 cells for detection of Kindlin/FERMT1 using Anti- Kindlin/FERMT1 Recombinant Rabbit Monoclonal Antibody (Product # 701830, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Kindlin/FERMT1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
701830
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
7H7L9
Immunogen
Protein corresponding to Human FERMT1 (aa 200-409)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2-7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Equine, Bovine, Pig and Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fermitin family member 1; FLJ20116; FLJ23423; kindlerin; kindlin 1; kindlin syndrome protein; RP5-1056H1.1; similar to Caenorhabditis elegans Unc-112 related protein 1; unc-112-related protein 1; UNC112 related protein 1; unnamed protein product
Gene Aliases: C20orf42; DTGCU2; KIND1; UNC112A; URP1
UniProt ID: (Human) Q9BQL6
Entrez Gene ID: (Human) 55612
positive regulation of cell-matrix adhesion
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of gene expression
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of integrin activation
positive regulation of cell adhesion mediated by integrin
negative regulation of protein import into nucleus
keratinocyte proliferation
keratinocyte migration
negative regulation of timing of anagen
positive regulation of transforming growth factor beta production
basement membrane organization
negative regulation of canonical Wnt signaling pathway
establishment of epithelial cell polarity
positive regulation of wound healing, spreading of epidermal cells
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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