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Invitrogen
CBX8 Recombinant Rabbit Monoclonal Antibody (4H2L5)
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FIGURE: 1 / 5
CBX8 Antibody (703495) in ICC/IF
For immunofluorescence analysis, HeLa cells were fixed for detection of endogenous CBX8 using Anti-CBX8 Recombinant Rabbit Monoclonal Antibody (Product # 703495, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 conjugate (Product # A32731, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CBX8 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). Pan... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
703495
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
4H2L5
Immunogen
Protein corresponding to human CBX8 [aa81-aa281]
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2-7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Mouse, Rat, Bovine.
Target Information
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromobox homolog 8 (Pc class homolog, Drosophila); HPC3; Pc class 3 homolog; PC3; similar to polycomb; polycomb 3; polycomb group protein; rectachrome 1; unnamed protein product
Gene Aliases: PC3; RC1
UniProt ID: (Human) Q9HC52
Entrez Gene ID: (Human) 57332
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
heterochromatin assembly
positive regulation of collagen biosynthetic process
positive regulation of DNA repair
negative regulation of transcription, DNA-templated
cellular response to hydrogen peroxide
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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