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Invitrogen
CDKL5 Recombinant Rabbit Monoclonal Antibody (1H57L44)
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FIGURE: 1 / 5
CDKL5 Antibody (703756) in ICC/IF
For immunofluorescence analysis, SH-SY5Y cells were fixed and permeabilized for detection of endogenous CDKL5 using Anti-CDKL5 Recombinant Rabbit Monoclonal Antibody (Product # 703756, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CDKL5 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Pro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
703756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
1H57L44
Immunogen
Protein corresponding to human CDKL5 [aa636-aa774]
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2-7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Bovine.
Target Information
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin dependent kinase 5 transcript; protein kinase; RP1-245G19.3; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9; unnamed protein product
Gene Aliases: CFAP247; DEE2; EIEE2; ISSX; STK9
UniProt ID: (Human) O76039, (Mouse) Q3UTQ8
Entrez Gene ID: (Human) 6792, (Mouse) 382253, (Rat) 100362725
neuron migration
protein localization to nucleus
positive regulation of Rac protein signal transduction
positive regulation of axon extension
regulation of dendrite development
positive regulation of dendrite morphogenesis
modulation of synaptic transmission
regulation of cell cycle
positive regulation of dendritic spine development
regulation of postsynapse organization
regulation of cilium assembly
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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