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Invitrogen

CREB Recombinant Superclonal™ Antibody (3HCLC)

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CREB Recombinant Superclonal™ Antibody (3HCLC)

Product Details

710149

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunocytochemistry (ICC/IF)

1:500-1:5,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

3HCLC

Immunogen

Recombinant protein corresponding to amino acids 222-341 of human CREB
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532591

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer's Disease, histiocytoma and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: active transcription factor CREB; active transcription factor CREB-A; active transcription factor CREB-B; cAMP-response element-binding protein-1; CREB-1; CREB1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP response element-binding protein-1 alpha isoform; Cyclic AMP-responsive element-binding protein 1; delta CREB; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; unnamed protein product

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Gene Aliases: CREB; CREB-1; CREB1

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UniProt ID: (Human) P16220

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Entrez Gene ID: (Human) 1385

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding enzyme binding Hsp70 protein binding histone acetyltransferase binding cAMP response element binding identical protein binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding arrestin family protein binding sequence-specific double-stranded DNA binding
Process(es)
response to hypoxia regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation signal transduction transforming growth factor beta receptor signaling pathway axonogenesis lactation memory circadian rhythm regulation of cell size visual learning response to xenobiotic stimulus negative regulation of gene expression negative regulation of transcription by competitive promoter binding response to purine-containing compound response to activity pituitary gland development cell differentiation osteoclast differentiation mammary gland development positive regulation of transforming growth factor beta3 production secretory granule organization response to glucagon chemotaxis to arachidonic acid response to nicotine cellular response to hepatocyte growth factor stimulus response to erythropoietin cellular response to platelet-derived growth factor stimulus positive regulation of multicellular organism growth response to cocaine mRNA transcription from RNA polymerase II promoter regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process response to morphine response to ethanol positive regulation of fat cell differentiation positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter hormone secretion positive regulation of hormone secretion positive regulation of lipid biosynthetic process regulation of fibroblast proliferation rhythmic process protein stabilization positive regulation of cardiac muscle tissue development regulation of glial cell proliferation lung epithelium development lung saccule development Type I pneumocyte differentiation cellular response to zinc ion cellular response to retinoic acid cellular response to growth factor stimulus cellular response to fatty acid cellular response to transforming growth factor beta stimulus cAMP/PKA signal transduction positive regulation of long-term synaptic potentiation response to L-glutamate response to dehydroepiandrosterone positive regulation of membrane depolarization cellular response to forskolin cellular response to nerve growth factor stimulus cellular response to insulin-like growth factor stimulus cellular response to leukemia inhibitory factor response to hypobaric hypoxia regulation of testosterone biosynthetic process
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