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Product Details
710260
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
43HCLC
Immunogen
Peptide corresponding to amino acids 60-71 of human Apo A2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with non-human primate and mouse based on sequence homology.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL, and VLDL particles of human serum are often used to estimate an individual's relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins ( especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease that measurements of lipoprotein particles (especially HDL and LDL). The apolipoproteins are derived from human plasma by density gradient ultracentrifugation and HPLC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APO A2; Apo-AII; Apolipoprotein; Apolipoprotein A-II; Apolipoprotein A2; Apolipoprotein AII; unnamed protein product
Gene Aliases: Apo-AII; ApoA-II; APOA2; APOAII
UniProt ID: (Human) P02652, (Rat) P04638
Entrez Gene ID: (Human) 336, (Rat) 25649
receptor binding
lipid transporter activity
protein binding
phospholipid binding
high-density lipoprotein particle binding
lipid binding
cholesterol binding
enzyme binding
heat shock protein binding
phosphatidylcholine binding
apolipoprotein receptor binding
protein homodimerization activity
protein heterodimerization activity
receptor agonist activity
lipase inhibitor activity
phosphatidylcholine-sterol O-acyltransferase activator activity
high-density lipoprotein particle receptor binding
intermembrane cholesterol transfer activity
cholesterol transporter activity
apolipoprotein
negative regulation of cytokine production involved in immune response
triglyceride metabolic process
phosphatidylcholine biosynthetic process
lipid transport
signal transduction
cholesterol metabolic process
phospholipid catabolic process
response to glucose
negative regulation of very-low-density lipoprotein particle remodeling
protein oxidation
peptidyl-methionine modification
regulation of intestinal cholesterol absorption
cholesterol transport
regulation of protein stability
negative regulation of cholesterol transport
positive regulation of interleukin-8 production
cholesterol efflux
phospholipid efflux
triglyceride-rich lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
diacylglycerol catabolic process
positive regulation of phagocytosis
protein stabilization
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
negative regulation of cholesterol import
cellular response to lipoprotein particle stimulus
cellular response to beta-amyloid
acute inflammatory response
negative regulation of cytokine secretion involved in immune response
protein folding
positive regulation of cholesterol esterification
organ regeneration
response to drug
positive regulation of catalytic activity
response to estrogen
positive regulation of interleukin-8 biosynthetic process
response to glucocorticoid
negative regulation of lipase activity
negative regulation of cholesterol transporter activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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