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FIGURE: 1 / 2
PSD93 Antibody (711031) in ICC/IF
For immunofluorescence analysis SH-SY5Y cells were fixed and permeabilized for detection of DLG2/PSD93/CHAPSYN-110 using Anti-DLG2/PSD93/CHAPSYN-110 Recombinant Rabbit Superclonal™ Antibody (Product # 711031, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of DLG2/PSD93/CHAPSYN-110 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
711031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
7HCLC
Immunogen
Protein corresponding to Human DLG2 (aa 250-430)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2-7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Rat and Mouse.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticiyt. PSD-93 is believed to participate in the clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-1; chapsyn-110; discs large MAGUK scaffold protein 2 eta; discs large MAGUK scaffold protein 2 gamma; discs, large homolog 2; discs, large homolog 2, chapsyn-110; postsynaptic density protein PSD-93; protein phosphatase 1, regulatory subunit 58; PSD-93 protein; unnamed protein product
Gene Aliases: A330103J02Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; Dlgh2; Gm1197; Gm21505; PPP1R58; PSD-93; PSD93
UniProt ID: (Human) Q15700, (Mouse) Q91XM9
Entrez Gene ID: (Human) 1740, (Mouse) 23859
chemical synaptic transmission
nervous system development
sensory perception of pain
protein localization to synapse
cellular response to potassium ion
receptor clustering
neuronal ion channel clustering
clustering of voltage-gated potassium channels
establishment or maintenance of epithelial cell apical/basal polarity
receptor localization to synapse
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of postsynaptic density structure
anterograde axonal protein transport
retrograde axonal protein transport
neurotransmitter receptor localization to postsynaptic specialization membrane
GMP metabolic process
GDP metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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