CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.
AuthorsGonsky R, Deem RL, Young HA, Targan SR,
JournalEur J Immunol
PubMed ID12731040
'The pathways leading to activation of mucosal lamina propria (LP) T cells differ from those of peripheral T cells. LP T cells exhibit enhanced IFN-gamma secretion when activated through the CD2 pathway. This study demonstrates CD2 signaling is followed by activation of STAT proteins in both peripheral blood mononuclear cells ... More
A novel VIP signaling pathway in T cells cAMP-->protein tyrosine phosphatase (SHP-2?)-->JAK2/STAT4-->Th1 differentiation.
AuthorsLiu L, Yen JH, Ganea D,
JournalPeptides
PubMed ID17462790
Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several mechanisms operate in the Th1/Th2 shift induced ... More
Role of H1 receptors in histamine-mediated up-regulation of STAT4 phosphorylation.
AuthorsLiu Z, Kharmate G, Patterson E, Khan MM,
JournalInt Immunopharmacol
PubMed ID16428084
Histamine shifts TH1/TH2 cytokine balance from TH1 to TH2 cytokines and regulates the function of lymphocytes after binding to histamine receptors. The phosphorylation of STAT factors and the translocation to the nucleus are important steps in the regulation of TH1/TH2 cytokine balance. This study was designed to investigate the effects ... More