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Invitrogen
PAX2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
71-6000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Sheep,
Rat,
Xenopus,
Zebrafish
Published species
Chicken,
Cynomolgus monkey,
Dog,
Human,
Mouse,
Rat,
Rhesus monkey,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A GST-Pax-2 fusion protein derived from the C-terminal domain (aa188-385) of the murine Pax-2 protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gene; thus, suggesting that WT1 can directly repress pax-2 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: optic disc coloboma; paired box gene 2; paired box homeotic gene 2; paired box protein 2
Gene Aliases: FSGS7; Opdc; PAPRS; PAX-2
UniProt ID: (Human) Q02962, (Mouse) P32114
Entrez Gene ID: (Sheep) 100422802, (Human) 5076, (Mouse) 18504, (Rat) 293992
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific double-stranded DNA binding
C2H2 zinc finger domain binding
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
metanephros development
ureteric bud development
branching involved in ureteric bud morphogenesis
cell fate determination
kidney development
mesonephros development
neural tube closure
optic cup morphogenesis involved in camera-type eye development
mesenchymal to epithelial transition involved in metanephros morphogenesis
retinal pigment epithelium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
sensory organ development
mesodermal cell fate specification
positive regulation of cell proliferation
glial cell differentiation
optic nerve development
optic nerve morphogenesis
optic nerve structural organization
vestibulocochlear nerve formation
pancreas development
regulation of metanephros size
ureter maturation
pronephric field specification
inner ear morphogenesis
regulation of apoptotic process
camera-type eye development
negative regulation of apoptotic process
regulation of programmed cell death
negative regulation of programmed cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ morphogenesis
system development
pronephros development
brain morphogenesis
stem cell differentiation
positive regulation of epithelial cell proliferation
mesenchymal to epithelial transition
ureteric bud morphogenesis
paramesonephric duct development
optic chiasma development
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to glucose stimulus
dopaminergic neuron differentiation
metanephric mesenchyme development
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
metanephric mesenchymal cell differentiation
mesonephric tubule development
mesonephric tubule formation
mesonephric duct development
nephric duct formation
ureter development
ureter morphogenesis
metanephric collecting duct development
metanephric epithelium development
metanephric distal convoluted tubule development
metanephric nephron tubule formation
positive regulation of metanephric glomerulus development
regulation of metanephric nephron tubule epithelial cell differentiation
cochlea development
cochlea morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of reactive oxygen species metabolic process
positive regulation of metanephric DCT cell differentiation
positive regulation of optic nerve formation
response to nutrient levels
cellular response to epidermal growth factor stimulus
axonogenesis
visual perception
cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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