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NeoBiotechnologies

Villin (GI-Mucosal and Urogenital Brush Border Marker) Monoclonal Antibody (VIL1/1314)

View all (56) Villin antibodies

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Villin (GI-Mucosal and Urogenital Brush Border Marker) Monoclonal Antibody (VIL1/1314)

Product Details

7429-MSM1-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

0.25-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

VIL1/1314

Immunogen

Recombinant human Villin fragment (around aa179-311).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: OTTHUMP00000207159; unnamed protein product; Villin-1

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Gene Aliases: D2S1471; VIL; VIL1

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UniProt ID: (Human) P09327

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Entrez Gene ID: (Human) 7429

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Function(s)
actin binding calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding lysophosphatidic acid binding identical protein binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process actin filament binding
Process(es)
intestinal D-glucose absorption apoptotic process cytoskeleton organization actin filament organization epidermal growth factor receptor signaling pathway actin polymerization or depolymerization regulation of cell shape response to bacterium positive regulation of epithelial cell migration actin filament polymerization actin filament depolymerization positive regulation of cell migration positive regulation of actin filament depolymerization epithelial cell differentiation positive regulation of actin filament bundle assembly regulation of microvillus length cellular response to hepatocyte growth factor stimulus positive regulation of multicellular organism growth positive regulation of cellular component biogenesis actin filament severing barbed-end actin filament capping regulation of actin nucleation actin filament capping cytoplasmic actin-based contraction involved in cell motility regulation of wound healing protein-containing complex assembly cellular response to epidermal growth factor stimulus positive regulation of lamellipodium organization terminal web assembly positive regulation of protein localization to plasma membrane regulation of lamellipodium morphogenesis positive regulation of lamellipodium morphogenesis
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