Mass spectrometry is essential for studying biological compounds. However, many of the buffers and reagents used for sample preparation interfere with mass spectrometry analysis, leading to poor-quality spectra and reduced sensitivity. Pierce Peptide Desalting Spin Columns are designed to remove many of the interfering hydrophilic sample contaminants with minimal sample loss, thus enabling sensitive and comprehensive analysis of digested protein samples by mass spectrometry.

• Remove MS-interfering contaminants—significantly reduces signal suppression and improves sensitivity in mass spectrometry
• High binding capacity—hydrophobic polymer-based resin allows for recovery of peptide loads of native and TMT-labeled peptides from 5 µg to 5 mg
• Easy to use—resin is provided in single-use spin column format that fits common 2-mL tubes
• Compatible—resin is validated with a variety of complex samples, including TMT-labeled peptides, and is stable under extreme pH conditions