Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL.
AuthorsNguyen HT, Geens M, Mertzanidou A, Jacobs K, Heirman C, Breckpot K, Spits C,
JournalMol Hum Reprod
PubMed ID24217388
Gain of 20q11.21 is a chromosomal abnormality that is recurrently found in human pluripotent stem cells and cancers, strongly suggesting that this mutation confers a proliferative or survival advantage to these cells. In this work we studied three human embryonic stem cell (hESC) lines that acquired a gain of 20q11.21 ... More
STAT3 and MCL-1 associate to cause a mesenchymal epithelial transition.
AuthorsRenjini AP, Titus S, Narayan P, Murali M, Kumar Jha R, Laloraya M,
Journal
PubMed ID24481815
'Embryo implantation is effected by a myriad of signaling cascades acting on the embryo-endometrium axis. Here we show, by using MALDI TOF analysis, far-western analysis and colocalization and co-transfection studies, that STAT3 and MCL-1 are interacting partners during embryo implantation. We show in vitro that the interaction between the two ... More