Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease.

• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays

Related Links:
LRRK2 Tools for Advancing Parkinson's Disease Research
LanthaScreen™ Kinase Activity Assay
LanthaScreen™ Eu Kinase Binding Assay