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Bethyl Laboratories

EZH2 Recombinant Rabbit Monoclonal Antibody (BLR311M)

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Product Details

A700-311

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR311M

Immunogen

Recombinant antibody was purified from cell culture supernatant. Immunogen was a peptide representing a region between residue 701 and the C-terminus (701-746) of human Histone-lysine N-methyltransferase EZH2 using the numbering given in entry NP_004447.2 (Gene ID 2146).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

purified

Storage buffer

PBS, pH 6.8-7.4

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

EZH2 (Histone-lysine N-methyltransferase) is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Mutations affecting EZH2 can cause Weaver syndrome (WVS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: an; enhancer of zeste homolog 2; enhancer of zeste homolog 2; transcription repressor; chromatin modifier; ENX 1; EZH 2; EZH-2; lysine N-methyltransferase 6; OTTHUMP00000213774; OTTHUMP00000213778; OTTHUMP00000213779; OTTHUMP00000213780; putative transcriptional regulator; unnamed protein product

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Gene Aliases: ENX-1; ENX1; Enx1h; EZH2b; KMT6; KMT6A; mKIAA4065; WVS; WVS2

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UniProt ID: (Human) Q15910, (Mouse) Q61188

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Entrez Gene ID: (Human) 2146, (Mouse) 14056

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription corepressor binding DNA binding chromatin binding transcription corepressor activity RNA binding protein binding protein-lysine N-methyltransferase activity chromatin DNA binding nucleosome binding histone methyltransferase activity histone binding ribonucleoprotein complex binding sequence-specific DNA binding histone methyltransferase activity (H3-K27 specific) primary miRNA binding lncRNA binding histone H3 methyltransferase activity histone H3K27 trimethyltransferase activity promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling regulation of transcription, DNA-templated positive regulation of cell proliferation negative regulation of gene expression positive regulation of epithelial to mesenchymal transition hippocampus development B cell differentiation positive regulation of cell migration chromatin silencing by small RNA heterochromatin assembly telomeric heterochromatin assembly response to estradiol regulation of circadian rhythm positive regulation of MAP kinase activity positive regulation of GTPase activity negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway cell development synaptic transmission, GABAergic positive regulation of protein serine/threonine kinase activity regulation of kidney development facultative heterochromatin formation positive regulation of dendrite development negative regulation of cytokine production involved in inflammatory response positive regulation of cell cycle G1/S phase transition regulation of protein phosphorylation methylation-dependent chromatin silencing regulation of transcription from RNA polymerase II promoter gene expression regulation of gene expression regulation of gliogenesis skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration cardiac muscle hypertrophy in response to stress cerebellar cortex development negative regulation of transcription elongation from RNA polymerase II promoter cellular response to trichostatin A hepatocyte homeostasis regulation of cell proliferation negative regulation of epidermal cell differentiation regulation of neurogenesis negative regulation of striated muscle cell differentiation cellular response to hydrogen peroxide G1 to G0 transition protein localization to chromatin immunoglobulin heavy chain V-D-J recombination liver regeneration constitutive heterochromatin formation response to tetrachloromethane negative regulation of G1/S transition of mitotic cell cycle
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