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Bethyl Laboratories

MEF2C Recombinant Rabbit Monoclonal Antibody (BLR327M)

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MEF2C Recombinant Rabbit Monoclonal Antibody (BLR327M)

Product Details

A700-327

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunoprecipitation (IP)

6 µL/mg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR327M

Immunogen

Recombinant antibody was purified from cell culture supernatant. Immunogen was a peptide representing a region between residue 425 and 475 of human Myocyte-specific enhancer factor 2C using the numbering given in entry NP_002388.2 (Gene ID 4208).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

purified

Storage buffer

PBS, pH 6.8-7.4

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MADS box transcription enhancer factor 2, polypeptide C; unnamed protein product

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Gene Aliases: 5430401D19Rik; 9930028G15Rik; C5DELq14.3; DEL5q14.3; Mef2; NEDHSIL

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UniProt ID: (Human) Q06413, (Mouse) Q8CFN5

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Entrez Gene ID: (Human) 4208, (Mouse) 17260

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding AT DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone deacetylase binding protein heterodimerization activity protein dimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding chromatin binding enzyme binding sequence-specific DNA binding HMG box domain binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade blood vessel development osteoblast differentiation neuron migration B cell homeostasis heart looping endochondral ossification blood vessel remodeling chondrocyte differentiation germinal center formation regulation of germinal center formation response to ischemia primary heart field specification secondary heart field specification outflow tract morphogenesis sinoatrial valve morphogenesis cardiac ventricle formation regulation of transcription, DNA-templated humoral immune response axon guidance heart development skeletal muscle tissue development muscle cell fate determination learning or memory gene expression positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression neural crest cell differentiation cardiac muscle hypertrophy in response to stress cell differentiation neuron differentiation platelet formation monocyte differentiation negative regulation of ossification melanocyte differentiation positive regulation of bone mineralization positive regulation of B cell proliferation embryonic heart tube development skeletal muscle cell differentiation cellular response to trichostatin A B cell proliferation positive regulation of MAPK cascade regulation of neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration cell fate commitment regulation of megakaryocyte differentiation positive regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurotransmitter secretion regulation of synaptic plasticity positive regulation of skeletal muscle tissue development neuron development cell morphogenesis involved in neuron differentiation embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation B cell receptor signaling pathway smooth muscle cell differentiation regulation of synapse assembly regulation of synaptic transmission, glutamatergic cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation palate development regulation of synaptic activity positive regulation of cardiac muscle cell proliferation excitatory postsynaptic potential transdifferentiation regulation of sarcomere organization cartilage morphogenesis regulation of dendritic spine development renal tubule morphogenesis cellular response to lipopolysaccharide cellular response to calcium ion cellular response to retinoic acid cellular response to growth factor stimulus cellular response to parathyroid hormone stimulus cellular response to xenobiotic stimulus cellular response to fluid shear stress semaphorin-plexin signaling pathway cellular response to transforming growth factor beta stimulus positive regulation of cell proliferation in bone marrow glomerulus morphogenesis nephron tubule epithelial cell differentiation sympathetic neuron axon guidance NMDA selective glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of vascular endothelial cell proliferation positive regulation of macrophage apoptotic process positive regulation of cardiac muscle cell differentiation positive regulation of behavioral fear response epithelial cell proliferation involved in renal tubule morphogenesis positive regulation of skeletal muscle cell differentiation nervous system development muscle organ development myotube differentiation animal organ development
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