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Bethyl Laboratories
Rad21 Recombinant Rabbit Monoclonal Antibody (BLR052F)
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FIGURE: 1 / 3
Rad21 Antibody (A700-052) in WB
Detection of human Rad21 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, Jurkat, HEK293T, RKO, GaMG, MCF-7, A-549, and U2OS cells prepared using NETN lysis buffer. Antibody: Rabbit anti-Rad21 recombinant monoclonal antibody [BLR052F] (Product # A700-052 lot 1) used at 1:1,000. Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). Detection: Chemiluminescence with an exposure time of 3 seconds. Lower panel: Rabbit anti-MED1 recombinant monoclonal antibody (A700-037).
Product Details
A700-052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR052F
Immunogen
Peptide representing a region between residue 581 and the C-terminus (residue 631) of human Double-strand-break repair protein Rad21 homolog.
Conjugate
Form
Liquid
Concentration
40 µg/mL
Purification
purified
Storage buffer
BBS, pH 7.8 to 8.6, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; h NXP-1; hHR21; HR21spA; KIAA0078; KIAA0078RAD21; kleisin; mHR21; Nuclear matrix protein 1; NXP-1; Pokeweed agglutinin-binding protein 29; protein involved in DNA double-strand break repair; PW29; RAD21 homolog; SCC1 homolog; sister chromatid cohesion 1; unnamed protein product
Gene Aliases: CDLS4; hHR21; HR21; HRAD21; KIAA0078; MCD1; MGS; mKIAA0078; NXP1; RAD21; SCC1
UniProt ID: (Human) O60216, (Mouse) Q61550
Entrez Gene ID: (Human) 5885, (Mouse) 19357
response to hypoxia
DNA repair
double-strand break repair
DNA recombination
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
chromosome segregation
sister chromatid cohesion
reciprocal meiotic recombination
positive regulation of gene expression
negative regulation of gene expression
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of interleukin-1 beta production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
establishment of mitotic sister chromatid cohesion
establishment of meiotic sister chromatid cohesion
negative regulation of glial cell apoptotic process
negative regulation of neuron apoptotic process
negative regulation of mitotic metaphase/anaphase transition
positive regulation of sister chromatid cohesion
cell division
protein localization to chromatin
chromatin looping
replication-born double-strand break repair via sister chromatid exchange
transcription from RNA polymerase II promoter
cell cycle
mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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