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Invitrogen
Ghrelin Monoclonal Antibody (45)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
ABS 050-45-02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, lambda
Class
Monoclonal
Type
Antibody
Clone
45
Immunogen
Synthetic human Ser3-octanoyl ghrelin-28.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.05 mg/mL
Amount
420 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: ABS 050-45-02 binds human ghrelin and des-acyl ghrelin, and showed ~5% cross-Specificity with rat ghrelin in a sandwich ELISA using ABS 052-121 as biotinylated detection antibody.
Reactivity: ABS 050-45-02 binds human ghrelin in solution. ABS 050-45-02 can be used as a capture antibody in a sandwich ELISA using biotinylated detection antibody ABS 052-121-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an the ligand for the growth hormone secretagogue receptor type 1 and is involved in regulating growth hormone release. Ghrelin has an appeptite-stimulating effect and induces adiposity and stimulates gastric acid secretion. Obestatin may be the ligand for the orphan G protein-coupled receptor GPR39 and is involved in satiety and can have an appetite-reducing effect resulting in decreased food intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMCBX1; appetite-regulating hormone isoform In2c; FIP-3; FIP3; Fip3p; ghrelin 27; ghrelin 28; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin; ghrelin/obestatin preprohormone; ghrelin/obestatin prepropeptide; growth hormone-releasing peptide; IKK-gamma; In2c-preproghrelin; IP; IP1; IP2; IPD2; motilin-related peptide; NEMO; OTTHUMP00000207794; OTTHUMP00000207795; OTTHUMP00000207796; OTTHUMP00000207798; prepro-appetite regulatory hormone; preproghrelin
Gene Aliases: MTLRP
UniProt ID: (Human) Q9UBU3
Entrez Gene ID: (Human) 51738
gastric acid secretion
negative regulation of endothelial cell proliferation
glucose metabolic process
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
actin polymerization or depolymerization
adult feeding behavior
response to hormone
hormone-mediated signaling pathway
dendrite development
negative regulation of angiogenesis
growth hormone secretion
response to nutrient levels
positive regulation of insulin secretion
regulation of response to food
positive regulation of response to food
positive regulation of appetite
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of growth rate
positive regulation of multicellular organism growth
regulation of cell proliferation
negative regulation of circadian sleep/wake cycle, REM sleep
negative regulation of apoptotic process
cortisol secretion
positive regulation of MAPK cascade
response to estrogen
positive regulation of growth
positive regulation of circadian sleep/wake cycle, non-REM sleep
decidualization
negative regulation of inflammatory response
cartilage development
positive regulation of corticotropin secretion
positive regulation of cortisol secretion
response to electrical stimulus
positive regulation of synapse assembly
regulation of transmission of nerve impulse
positive regulation of growth hormone secretion
positive regulation of growth hormone receptor signaling pathway
postsynaptic modulation of chemical synaptic transmission
regulation of postsynapse organization
positive regulation of small intestinal transit
positive regulation of cold-induced thermogenesis
positive regulation of bone development
positive regulation of sprouting angiogenesis
positive regulation of eating behavior
positive regulation of adipose tissue development
positive regulation of gastro-intestinal system smooth muscle contraction
positive regulation of gastric mucosal blood circulation
positive regulation of small intestine smooth muscle contraction
regulation of gastric motility
positive regulation of vascular endothelial cell proliferation
positive regulation of feeding behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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