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          • Primary Antibodies ›
          • Amyloid Oligomers Antibodies

          Invitrogen

          Oligomer A11 Polyclonal Antibody

          12 Published Figures
          123 References
          View all (3) Amyloid Oligomers antibodies

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          Cite Oligomer A11 Polyclonal Antibody

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          • Antibody Testing Data (1)
          • Published Figures (12)
          Oligomer A11 Antibody in Western Blot (WB)
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          Oligomer A11 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 13

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          Oligomer A11 Antibody (AHB0052) in WB

          Rabbit Anti-Oligomer (A11) Polyclonal Antibody. 1 µg of soluble Abeta42 monomers, Abeta42 oligomers, Ab42 fibrils, IAPP oligomers and alpha-Synuclein oligomers was applied to a nitrocellulose membrane and probed with Rabbit Anti-oligomer (A11) polyclonal antibody (top row; Product # AHB0052) or with 6E10 (bottom row, Product # 44-352). Anti-oligomer antibody recognizes all types of oligomers, but not monomers or fibrils. 6E10 recognizes all species of Abeta without regard to conformation, but not IAPP or alpha-Synuclein. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Immunohistochemistry (PFA fixed), Immunocytochemistry (IHC (PFA), ICC/IF)
          Oligomer A11 Antibody in Immunohistochemistry (Frozen) (IHC (F))
          Oligomer A11 Antibody in Immunohistochemistry (IHC)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in Western Blot (WB)
          Oligomer A11 Antibody in ELISA (ELISA)
          Oligomer A11 Antibody in Dot Blot (DB)
          Oligomer A11 Antibody in Dot Blot (DB)
          Oligomer A11 Antibody in Dot Blot (DB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Product Details

          AHB0052

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          View 33 publications 33 publications

          Immunohistochemistry (IHC)

          1-5 µg/mL
          View 18 publications 18 publications

          Immunohistochemistry (PFA fixed) (IHC (PFA))

          -
          View 1 publication 1 publication

          Immunohistochemistry (Frozen) (IHC (F))

          -
          View 1 publication 1 publication

          Immunohistochemistry - Free Floating (IHC (Free))

          -
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          -
          View 16 publications 16 publications

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          0.1-1 µg/mL
          View 5 publications 5 publications

          Immunoprecipitation (IP)

          -
          View 2 publications 2 publications

          Neutralization (Neu)

          Assay-dependent
          View 1 publication 1 publication

          Dot blot (DB)

          0.1-1 µg/mL
          View 33 publications 33 publications

          Miscellaneous PubMed (Misc)

          -
          View 11 publications 11 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Bacteria, Cat, Cynomolgus monkey, Fruit fly, Human, Mouse, Nematode, Rat, Zebrafish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic molecular mimic of soluble oligomers.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1.0 mg/mL

          Amount

          50 µg

          Purification

          purified

          Storage buffer

          PBS, pH 7.4

          Contains

          0.1% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10376183

          Product Specific Information

          This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. A11 reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils. A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein and yeast prion Sup35.

          Oligomeric AB42 is recommended as a positive control, monomeric and fibrillar AB42 as negative controls.

          Target Information

          Amyloid beta oligomers are aggregates of the amyloid beta peptide, which is derived from the amyloid precursor protein (APP) through enzymatic cleavage. These oligomers are considered to be neurotoxic and have been implicated in the pathogenesis of Alzheimer's disease. Structurally, these oligomers can vary in size and form, ranging from dimers to large aggregates, and their formation is influenced by factors such as the peptide concentration, pH, and presence of metals. Functionally, these oligomers disrupt cellular processes, leading to synaptic dysfunction, oxidative stress, and ultimately neuronal death. They exert their toxic effects by interacting with cell membranes, forming pores, and triggering intracellular signaling pathways that result in neurodegeneration. The exact mechanisms by which Amyloid beta oligomers contribute to Alzheimer's disease are still under investigation, but they are a key focus of therapeutic strategies aimed at mitigating the progression of the disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: ABPP; AG; alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid A4; amyloid beta; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid beta precursor protein (ABPP); amyloid beta protein; amyloid beta protein 695; amyloid beta-protein precursor; amyloid precursor protein; amyloid protein; amyloidogenic glycoprotein; appican; beta-amyloid A4; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; beta-amyloid protein; cerebral vascular amyloid peptide; peptidase nexin-II; protease nexin II; protease nexin-II; testicular tissue protein Li 2; unnamed protein product

          View more View less

          Gene Aliases: AAA; ABETA; ABPP; AD1; Adap; Ag; alpha-sAPP; APPI; betaApp; CTFgamma; CVAP; E030013M08Rik; PN-II; PN2; preA4

          View more View less

          UniProt ID: (Human) P05067, (Rat) P08592, (Mouse) P12023

          View more View less

          Entrez Gene ID: (Human) 351, (Rat) 54226, (Mouse) 11820

          View more View less

          Function(s)
          G-protein coupled receptor binding DNA binding chromatin binding serine-type endopeptidase inhibitor activity receptor binding frizzled binding insulin receptor binding integrin binding protein binding heparin binding peptidase activator activity enzyme binding peptidase inhibitor activity receptor activator activity acetylcholine receptor activator activity acetylcholine receptor binding apolipoprotein binding chemoattractant activity identical protein binding protein homodimerization activity heparan sulfate proteoglycan binding ephrin receptor binding transition metal ion binding protein heterodimerization activity receptor agonist activity low-density lipoprotein particle receptor binding RAGE receptor binding chaperone binding PTB domain binding growth factor receptor binding amylin binding protein serine/threonine kinase binding molecular function activator activity heparan sulfate binding RNA polymerase II core promoter proximal region sequence-specific DNA binding zinc ion binding protein kinase binding protein domain specific binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter microglial cell activation suckling behavior astrocyte activation involved in immune response regulation of transcription from RNA polymerase II promoter regulation of translation protein phosphorylation calcium ion transport cellular copper ion homeostasis endocytosis response to oxidative stress G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway chemical synaptic transmission axonogenesis central nervous system development learning or memory learning memory mating behavior locomotory behavior axo-dendritic transport cholesterol metabolic process negative regulation of cell proliferation associative learning adult locomotory behavior visual learning response to lead ion gene expression regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle response to auditory stimulus microglia development axon midline choice point recognition neuron remodeling dendrite development calcium-mediated signaling negative regulation of Wnt signaling pathway extracellular matrix organization forebrain development neuron projection development phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of synaptic transmission, cholinergic positive regulation of chemokine production positive regulation of interferon-gamma production positive regulation of interleukin-1 beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation regulation of toll-like receptor signaling pathway ionotropic glutamate receptor signaling pathway swimming behavior regulation of multicellular organism growth positive regulation of apoptotic process positive regulation of MAPK cascade regulation of neuron apoptotic process positive regulation of neuron apoptotic process innate immune response positive regulation of nitric oxide biosynthetic process response to ethanol negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of Toll signaling pathway positive regulation of glycolytic process positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade astrocyte activation regulation of long-term neuronal synaptic plasticity collateral sprouting in absence of injury positive regulation of inflammatory response regulation of synapse structure or activity synapse organization positive regulation of calcium-mediated signaling neuromuscular process controlling balance cognition positive chemotaxis positive regulation of membrane protein ectodomain proteolysis synaptic growth at neuromuscular junction regulation of protein metabolic process positive regulation of protein metabolic process protein homooligomerization protein tetramerization neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis regulation of neurotransmitter uptake low-density lipoprotein particle mediated signaling antimicrobial humoral immune response mediated by antimicrobial peptide protein trimerization positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to copper ion cellular response to manganese ion cellular response to cAMP cellular response to norepinephrine stimulus positive regulation of monocyte chemotaxis negative regulation of canonical Wnt signaling pathway modulation of excitatory postsynaptic potential hippocampal neuron apoptotic process positive regulation of gene expression, epigenetic positive regulation of cAMP/PKA signal transduction regulation of spontaneous synaptic transmission cytosolic mRNA polyadenylation negative regulation of protein localization to nucleus regulation of beta-amyloid clearance negative regulation of long-term synaptic potentiation positive regulation of long-term synaptic potentiation positive regulation of long term synaptic depression positive regulation of NIK/NF-kappaB signaling negative regulation of beta-amyloid formation regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of dendritic spine maintenance negative regulation of dendritic spine maintenance positive regulation of amyloid precursor protein catabolic process regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of blood circulation positive regulation of G protein-coupled receptor internalization positive regulation of endothelin production positive regulation of protein import cellular response to beta-amyloid regulation of presynapse assembly negative regulation of presynapse assembly positive regulation of response to endoplasmic reticulum stress regulation of amyloid fibril formation positive regulation of amyloid fibril formation amyloid fibril formation cellular response to nerve growth factor stimulus response to insulin-like growth factor stimulus neuron projection maintenance positive regulation of T cell migration positive regulation of excitatory postsynaptic potential positive regulation of extrinsic apoptotic signaling pathway response to yeast antibacterial humoral response antifungal humoral response regulation of Wnt signaling pathway lipoprotein metabolic process regulation of MAPK cascade defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive regulation of cell activation positive regulation of protein kinase B signaling NMDA selective glutamate receptor signaling pathway regulation of response to calcium ion long-term synaptic potentiation
          It has to be done as per old AB suggested Products section.

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