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Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers
Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers
Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers
Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers
Thermo Scientific™

Orbitrap™ Excedion™ Series Hybrid Mass Spectrometers

Expand your analytical horizons with Orbitrap Excedion MS for small-molecule MetID, Metabolomics/Lipidomics and EFS Research. Upgradeable in-lab to Orbitrap Excedion Pro MS for more advanced proteomics and biopharma analysis.
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Catalog NumberModel
BRE725570

Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology

BRE725571Orbitrap Excedion Pro BioPharma Mass Spectrometer
BRE725572Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology
BRE0067126Factory installed Electron Transfer Dissociation (ETD)
BRE0065480Field upgrade Electron Transfer Dissociation (ETD)
BRE725573Orbitrap Excedion Mass Spectrometer for MetID, Metabolomics, Proteomics and EFS research
BRE725574Orbitrap Excedion BioPharma Mass Spectrometer with mass range up to 8,000
Catalog number BRE725570
Price (USD)
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Model:

Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology

Experience confident small-molecule and multi-omics analysis in complex samples. Accelerate insights across metabolomics, drug metabolism, and environmental research with Orbitrap Excedion MS, a versatile high-resolution accurate-mass platform that delivers high sensitivity, extended dynamic range with eDR, and sub-ppm mass accuracy. Orbitrap Excedion MS can be upgraded in-lab to Orbitrap Excedion Pro MS, expanding capabilities for advanced proteomics and biopharma research, including extended mass detection up to m/z 12,000 with optional fast and sensitive ETD/EThcD fragmentation.

Metabolomics

Orbitrap Excedion MS enables deep metabolomic profiling with high sensitivity, extended dynamic range (eDR), and HRAM performance. Fast polarity switching, nano-flow capabilities, and integrated Compound Discoverer workflows support broad coverage, including single-cell lipidomics.

Metabolite Identification (MetID)

For MetID, Orbitrap Excedion MS combines HRAM and eDR to detect low-abundance metabolites alongside parent compounds. Sub-ppm mass accuracy and integrated workflows with Thermo Scientific™ Compound Discoverer Software and Mass MetaSite™ enable confident annotation.

Environmental & Food Safety (EFS)

Orbitrap Excedion MS delivers sensitive EFS research analysis with enhanced MS1sensitivity and eDR for trace-level detection. HRAM full-scan data supports confident suspect and non-target screening of PFAS and emerging contaminants.

BioPharma

Orbitrap Excedion BioPharma edition MS supports BioPharma analysis through a dedicated oligonucleotide mode with optimized pressure control, enabling intact mass, sequencing, and quantitative characterization of mRNA, oligonucleotides, and ADC-related species.

With in-lab upgrade to Orbitrap Excedion Pro BioPharma edition MS and optional fast and sensitive ETD fragmentation, users can expand biopharma and proteomics capabilities. Advanced fragmentation enables Asp/IsoAsp detection, Leu/Ile resolution, enhanced middle-down coverage, and near single-residue HDX-MS, supporting deep proteome, PTM, and immunopeptidomics analysis.

Specifications
Detection Limits
  • Full Scan: < 1.5 fg reserpine on column
  • MS2: < 1.5 fg reserpine on column
  • SIM: < 0.8 fg reserpine on column
Dimensions (D x W x H)29.8 x 21 x 27.6 in. (758 x 535 x 703 mm)
Dynamic RangeUp to 5 orders of magnitude intrascan
Fragmentation

Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard.
Electron Transfer Dissociation (ETD) for c/z ion fragmentation is factory installed.

Mass Accuracy
  • 1-point calibration for <3 ppm RMS drift over at least 4 weeks*
  • Internal lock mass calibration for <1 ppm RMS drift over 24 hours*
  • EASY-IC for <1 ppm RMS drift for at least 5 days*

Mass accuracy, single mass*

  • Internal calibration achieves <0.2 ppm RMS for m/z 262.63612 [MRFA2+] in positive mode
  • Internal calibration achieves <0.2 ppm RMS for m/z 362.96962 [Perfluoroheptanoic acid] in negative mode

*Under defined conditions

Model

Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology

MultiplexingUp to 20 precursor ions per scan
Max. ResolutionUp to 480,000 (FWHM) at 200 m/z
TypeOrbitrap LC-MS
Unit SizeEach

Frequently asked questions (FAQs)

What quantitative and qualitative data quality improvements does the Orbitrap Excedion Pro MS deliver?

The Thermo Scientific Orbitrap Excedion Pro MS brings qualitative improvements via richer fragmentation (ETD/EThcD) enabling complementary fragment ion types (b/y + c/z), which improves sequence coverage, discrimination of isobaric residues (e.g., leucine/isoleucine), and structural elucidation (e.g., PTMs, isoAsp modifications).

On the quantitative side, the enhanced dynamic-range mode (eDR) allows simultaneous detection of both high- and low-abundance analytes without saturation or loss of low peaks, which improves data accuracy and reproducibility in complex matrices.

The improved ion-transfer optics and optimized front end reduce losses of labile species and improve sensitivity (critical for low-input workflows).

What differentiates Orbitrap Excedion Pro MS from conventional HRAM instruments?

The Thermo Scientific Orbitrap Excedion Pro MS offers advanced fragmentation options and acquisition workflows: for example, optional Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) in a benchtop hybrid MS system, enabling rich fragmentation of peptides, proteins, and labile molecules. The system supports Hybrid-DIA (combining discovery-mode DIA with targeted sensitivity), as well as “Turbo TMT” modes optimized for high-plex TMT experiments.

Does the Orbitrap Excedion Pro MS support small-molecule (metabolomics/lipidomics) and large-biomolecule (proteomics/biopharma) workflows?

For small molecules, the Thermo Scientific Orbitrap Excedion Pro MS excels in high sensitivity and low-in-source fragmentation, helping enable discovery of more unknowns. For large biomolecules and biopharma, the BioPharma edition supports extended mass ranges (up to m/z ~12,000) and offers advanced fragmentation (ETD/EThcD) workflows for intact-protein and post-translational-modification (PTM) characterization. The Orbitrap Excedion Pro MS is a versatile hybrid MS platform suitable for metabolomics, lipidomics, proteomics, structural biology, and biopharmaceutical characterization.