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Thermo Scientific™
Orbitrap™ Excedion™ Pro Mass Spectrometers
Discover Thermo Scientific™ Orbitrap™ Excedion™ Pro Mass Spectrometers - next generation hybrid mass spectrometers with exceptional performance for proteins, peptides, and small molecules analysis.
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| Catalog Number | Model | Fragmentation |
|---|---|---|
| BRE725570 | Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. |
| BRE725571 | Orbitrap Excedion Pro BioPharma Mass Spectrometer | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. |
| BRE725572 | Orbitrap Excedion Pro Mass Spectrometer for metabolomics, lipidomics, proteomics, and structural biology | Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard. Electron Transfer Dissociation (ETD) for c/z ion fragmentation is optional as a field upgrade. |
| BRE0067126 | Factory installed Electron Transfer Dissociation (ETD) | Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation. |
| BRE0065480 | Field upgrade Electron Transfer Dissociation (ETD) | Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation. |
Catalog number BRE725570
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Model:
Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology
Fragmentation:
Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard.
Electron Transfer Dissociation (ETD) for c/z ion fragmentation is factory installed.
Enhance your research and achieve groundbreaking discoveries with Orbitrap Excedion Pro Hybrid Mass Spectrometers, with models to meet your specific needs.
The Orbitrap Excedion Pro BioPharma Mass Spectrometer delivers extended capabilities for biopharma characterization applications and higher order structural biology with mass detection up to m/z 12,000. In addition, optional fast and sensitive Electron Transfer Dissociation (ETD) and Electron-Transfer/Higher-Energy Collision Dissociation (EThcD) alternative fragmentation can be field or factory installed.
The core model Orbitrap Excedion Pro Mass Spectrometer offers exceptional performance for proteomics with advanced capabilities for sensitive non-targeted metabolomics and lipidomics analysis. Optional fast and sensitive ETD/EThcD can be factory or field installed for proteomics applications.
Elevate your biopharma characterization
- Detect low abundant Asp/IsoAsp isomerization
- Detailed structural elucidation: Discern Leucin and Isoleucin isobaric masses with great confidence
- Top-up the sequence coverage in middle-down analysis with fast radical driven fragmentation
Innovate higher-order structure characterization of biomolecules
- ETD fragmentation option enables near single residue resolution in bottom-up and top-down Hydrogen-Deuterium Exchange (HDX) analysis with high sensitivity for alternative fragmentation ETD in ion routing multipole and combination of EThcD in the ion routing multipole for detection in the Orbitrap mass analyzer
- Fast and sensitive ETD reaction of precursor ion with fluoranthene radical anions (m/z 202) injection into the IRM to generate a series of c/z-fragment ions. EThcD fragmentation enabled by reaccelerating ETD fragment ions into IRM for HCD fragmentation
- HDX-based MS offers a comprehensive and novel toolset for the analysis of protein conformation, conformation dynamics, and protein-protein interactions
Exceed in proteomics research
- Accurate quantification with extended dynamic range
- Hybrid-DIA
- Deep proteome coverage
- PTMs analysis with ETD fragmentation
- Immunopeptidomics with EThcD fragmentation
Discovery in metabolomics research
- Increased sensitivity up to 10x compound dependent
- Enhanced Dynamic Range (eDR)
- Increased unknown annotations
Simultaneously measure multiple parameters within a single experiment
Up to 20 precursor ions per scan
Specifications
Detection Limits
- Full Scan: < 1.5 fg reserpine on column
- MS2: < 1.5 fg reserpine on column
- SIM: < 0.8 fg reserpine on column
Dimensions (D x W x H)29.8 x 21 x 27.6 in. (758 x 535 x 703 mm)
Dynamic RangeUp to 5 orders of magnitude intrascan
Fragmentation
Higher Collisional Dissociation (HCD) for b/y ion fragmentation is included as standard.
Electron Transfer Dissociation (ETD) for c/z ion fragmentation is factory installed.
Includes
- 1-point calibration for <3 ppm RMS drift over at least 4 weeks*
- Internal lock mass calibration for <1 ppm RMS drift over 24 hours* EASY-IC for <1 ppm RMS drift for at least 5 days*
- Five orders of magnitude intrascan dynamic range* *Under defined conditions
Model
Orbitrap Excedion Pro Mass Spectrometer with EASY-ETD ion source for metabolomics, lipidomics, proteomics, and structural biology
MultiplexingUp to 20 precursor ions per scan
Max. ResolutionUp to 480,000 (FWHM) at 200 m/z
TypeOrbitrap LC-MS
Unit SizeEach