Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction.
AuthorsLin P, Correa D, Lin Y, Caplan AI,
JournalPLoS One
PubMed ID21887340
'Human mesenchymal stem cells (hMSCs) can be engineered to express specific genes, either for their use in cell-based therapies or to track them in vivo over long periods of time. To obtain long-term expression of these genes, a lentivirus- or retrovirus-mediated cell transduction is often used. However, given that the ... More