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PDX1 Monoclonal Antibody (OTI3H3), TrueMAB™

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PDX1 Monoclonal Antibody (OTI3H3), TrueMAB™

Product Details

CF807372

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI3H3

Immunogen

Full length human recombinant protein of human PDX1 produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1

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Gene Aliases: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1

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UniProt ID: (Human) P52945

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Entrez Gene ID: (Human) 3651

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding macromolecular complex binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development type B pancreatic cell differentiation glucose metabolic process generation of precursor metabolites and energy transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter smoothened signaling pathway cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to glucose organ morphogenesis response to iron(II) ion response to chlorate glucose mediated signaling pathway regulation of gene expression morphogenesis of embryonic epithelium insulin secretion cell differentiation pancreas development exocrine pancreas development endocrine pancreas development organ regeneration response to nutrient levels positive regulation of insulin secretion response to vitamin response to lipid response to cytokine response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus enteroendocrine cell differentiation regulation of cell proliferation glucose homeostasis response to leucine response to alkaloid type B pancreatic cell proliferation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter digestive tract development stem cell differentiation epithelial cell proliferation negative regulation of epithelial cell proliferation response to glucocorticoid transdifferentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress response to fatty acid type B pancreatic cell apoptotic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cellular response to acadesine positive regulation of type B pancreatic cell proliferation negative regulation of type B pancreatic cell apoptotic process
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Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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