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OriGene

XDH Monoclonal Antibody (OTI1C10), TrueMAB™

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XDH Monoclonal Antibody (OTI1C10), TrueMAB™

Product Details

CF812777

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI1C10

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-280 of human XDH produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody

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Gene Aliases: XAN1; XDH; XDHA; XO; XOR; Xox-1; Xox1

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UniProt ID: (Human) P47989, (Rat) P22985, (Mouse) Q00519

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Entrez Gene ID: (Human) 7498, (Rat) 497811, (Mouse) 22436

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Function(s)
xanthine dehydrogenase activity xanthine oxidase activity iron ion binding protein binding oxidoreductase activity protein homodimerization activity molybdopterin cofactor binding metal ion binding flavin adenine dinucleotide binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding hypoxanthine dehydrogenase activity hypoxanthine oxidase activity FAD binding UDP-N-acetylmuramate dehydrogenase activity electron carrier activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity oxidoreductase activity, acting on CH-OH group of donors molybdenum ion binding oxidoreductase metabolite interconversion enzyme
Process(es)
allantoin metabolic process guanine catabolic process inosine catabolic process deoxyinosine catabolic process adenosine catabolic process deoxyadenosine catabolic process deoxyguanosine catabolic process AMP catabolic process IMP catabolic process lactation hypoxanthine catabolic process xanthine catabolic process iron-sulfur cluster assembly regulation of epithelial cell differentiation cellular amide catabolic process GMP catabolic process dGMP catabolic process dAMP catabolic process negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process response to aluminum ion negative regulation of gene expression bone resorption negative regulation of endothelial cell differentiation negative regulation of protein kinase B signaling oxidation-reduction process positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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