'The misfolding of the prion protein (PrP(c)) is a central event in prion diseases, yet the normal function of PrP(c) remains unknown. PrP(c) has putative roles in many cellular processes including signaling, survival, adhesion, and differentiation. Given the abundance of PrP(c) in the developing and mature mammalian CNS, we investigated ... More
Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.
AuthorsZhao L, Tian D, Xia M, Macklin WB, Feng Y,
JournalJ Neurosci
PubMed ID17079655
Alternative splicing of the qkI transcript generates multiple isoforms of the selective RNA-binding protein QKI, which play key roles in controlling the homeostasis of their mRNA targets. QKI deficiency in oligodendrocytes of homozygous quakingviable (qkV/qkV) mutant mice results in severe hypomyelination, indicating the essential function of QKI in myelinogenesis. However, ... More
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
AuthorsAoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA
JournalNat Neurosci
PubMed ID16311588
Uptake of the neurotransmitter glutamate is effected primarily by transporters expressed on astrocytes, and downregulation of these transporters leads to seizures and neuronal death. Neurons also express a glutamate transporter, termed excitatory amino acid carrier-1 (EAAC1), but the physiological function of this transporter remains uncertain. Here we report that genetically ... More
Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain.
AuthorsVeit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R
JournalJ Biol Chem
PubMed ID16330543
Here we describe a novel collagen belonging to the class of von Willebrand factor A (VWA) domain-containing proteins. This novel protein was identified by screening the EST data base and was subsequently recombinantly expressed and characterized as an authentic tissue component. The COL28A1 gene on human chromosome 7p21.3 and on ... More
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
Authors
JournalNat Immunol
PubMed ID34099917
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Authors
JournalElife
PubMed ID30747709
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice.
Authors
JournalNat Biotechnol
PubMed ID24531797
Synaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy.
Authors
JournalCell Rep
PubMed ID31618632
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Authors
JournalJ Clin Invest
PubMed ID35143418
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.