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CCR2 Monoclonal Antibody (4D12)

View all (34) CCR2 (CD192) antibodies

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CCR2 Monoclonal Antibody (4D12)

Product Details

H00001231-M01A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

4D12

Immunogen

CCR2 (NP_000639, 1 a.a. approximately 42 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GA

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cc-ckr2; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; Mcp1 receptor; Mcp1r; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; unnamed protein product

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Gene Aliases: CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD

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UniProt ID: (Human) P41597

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Entrez Gene ID: (Human) 729230

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Function(s)
G-protein coupled receptor activity chemokine receptor activity protein binding C-C chemokine receptor activity cytokine binding C-C chemokine binding CCR2 chemokine receptor binding chemokine (C-C motif) ligand 2 binding chemokine (C-C motif) ligand 12 binding chemokine (C-C motif) ligand 7 binding identical protein binding
Process(es)
blood vessel remodeling dendritic cell chemotaxis regulation of T cell cytokine production positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cellular calcium ion homeostasis chemotaxis inflammatory response immune response cellular defense response G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration JAK-STAT cascade response to wounding regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain calcium-mediated signaling cellular homeostasis positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production monocyte extravasation T-helper 17 cell chemotaxis negative regulation of eosinophil degranulation regulation of T cell differentiation positive regulation of alpha-beta T cell proliferation regulation of inflammatory response positive regulation of inflammatory response positive regulation of T cell activation positive regulation of synaptic transmission, glutamatergic cell chemotaxis chemokine-mediated signaling pathway cellular response to cytokine stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages inflammatory response to wounding positive regulation of cold-induced thermogenesis positive regulation of glutamate receptor signaling pathway macrophage migration positive regulation of thymocyte migration positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration
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