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Abnova

IL10 Monoclonal Antibody (1C10)

View all (97) IL-10 antibodies

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IL10 Monoclonal Antibody (1C10)

Product Details

H00003586-M03A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

1C10

Immunogen

IL10 (AAI04253.1, 74 a.a. approximately 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: FKGYLGCQAL SEMIQFYLEE VMPQAENQDP DIKAHVNSLG ENLKTLRLRL RRCHRFLPCE NKSKAVEQVK NAFNKLQEKG IYKAMSEFDI FINYIEAYMT MKIRN

Target Information

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cytokine synthesis inhibitory factor; H-IL-10; il 10; IL10; ILN; Interleukin; Interleukin10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor

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Gene Aliases: CSIF; GVHDS; IL-10; IL10A; TGIF

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UniProt ID: (Human) P22301

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Entrez Gene ID: (Human) 3586

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Function(s)
cytokine activity interleukin-10 receptor binding protein binding growth factor activity protein dimerization activity
Process(es)
negative regulation of cytokine production positive regulation of cytokine production positive regulation of endothelial cell proliferation response to molecule of bacterial origin positive regulation of immunoglobulin production negative regulation of cytokine production involved in immune response positive regulation of B cell apoptotic process immune response JAK-STAT cascade positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus regulation of gene expression negative regulation of autophagy response to activity response to inactivity cytokine-mediated signaling pathway hemopoiesis B cell differentiation leukocyte chemotaxis negative regulation of B cell proliferation response to lipopolysaccharide negative regulation of interferon-alpha production negative regulation of interleukin-1 production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production response to insulin negative regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion response to carbon monoxide type 2 immune response B cell proliferation negative regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of macrophage activation negative regulation of apoptotic process negative regulation of neuron apoptotic process negative regulation of nitric oxide biosynthetic process T-helper 1 cell differentiation regulation of isotype switching negative regulation of MHC class II biosynthetic process positive regulation of cell cycle positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade negative regulation of inflammatory response regulation of synapse organization regulation of B cell activation negative regulation of membrane protein ectodomain proteolysis response to glucocorticoid negative regulation of cytokine activity cellular response to lipopolysaccharide cellular response to estradiol stimulus negative regulation of chemokine (C-C motif) ligand 5 production endothelial cell apoptotic process liver regeneration interleukin-10-mediated signaling pathway positive regulation of plasma cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of response to wounding negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of complement-dependent cytotoxicity positive regulation of sprouting angiogenesis negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular smooth muscle cell proliferation negative regulation of endothelial cell apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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