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Abnova
MSX2 Monoclonal Antibody (1E8)
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Product Details
H00004488-M10A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1E8
Immunogen
MSX2 (AAH15509.1, 1 a.a. approximately 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK EASPLPAESA SAGATLRPLL LSGHGAREAH SPGPLVKPFE TASVKSENSE DGAAWMQEPG RYSPPPRHTS PTT
Target Information
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeobox protein; Homeobox protein Hox-8; Homeobox protein MSX-2; msh homeo box 2; msh homeobox homolog 2
Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1
UniProt ID: (Human) P35548
Entrez Gene ID: (Human) 4488
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
chondrocyte development
osteoblast development
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
epithelial to mesenchymal transition involved in endocardial cushion formation
endochondral bone growth
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of cell proliferation
organ morphogenesis
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
embryonic nail plate morphogenesis
wound healing
odontogenesis
embryonic digit morphogenesis
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of fat cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
embryonic morphogenesis
stem cell differentiation
cartilage development
positive regulation of catagen
bone trabecula formation
bone morphogenesis
cranial suture morphogenesis
frontal suture morphogenesis
branching involved in mammary gland duct morphogenesis
mammary gland epithelium development
cell surface receptor signaling pathway involved in heart development
enamel mineralization
cellular response to growth factor stimulus
cellular response to estradiol stimulus
activation of meiosis
mesenchymal cell apoptotic process
positive regulation of mesenchymal cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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