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Abnova
RNF41 Monoclonal Antibody (4C2)
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Product Details
H00010193-M01A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
4C2
Immunogen
RNF41 (NP_005776, 218 a.a. approximately 317 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: ISTPDAVLQA VIKRSLVESG CPASIVNELI ENAHERSWPQ GLATLETRQM NRRYYENYVA KRIPGKQAVV VMACENQHMG DDMVQEPGLV MIFAHGVEEI
Target Information
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. Nrdp1, also known as RNF41 (RING finger protein 41), SBBI03 or FLRF, is a 317 amino acid protein that contains one RING-type zinc finger and one SIAH-type zinc finger. Expressed in testis, ovary and prostate, Nrdp1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, Nrdp1 interacts with ErbB-3 and UBPY, thereby targeting them for proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase NRDP1; fetal liver ring finger; neuregulin receptor degradation protein-1; RING finger protein 41; ring finger protein 41, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase NRDP1; SBBI03; similar to Homo sapiens hypothetical SBBI03 protein mRNA with GenBank Accession Number AF077599; unnamed protein product
Gene Aliases: FLRF; NRDP1; RNF41; SBBI03
UniProt ID: (Human) Q9H4P4
Entrez Gene ID: (Human) 10193, (Rat) 362814
ubiquitin-protein transferase activity
erythropoietin receptor binding
interleukin-3 receptor binding
protein binding
zinc ion binding
transferase activity
enzyme binding
protein domain specific binding
receptor tyrosine kinase binding
small GTPase binding
identical protein binding
metal ion binding
ubiquitin protein ligase activity
acid-amino acid ligase activity
Ral GTPase binding
protein tag
protein polyubiquitination
autophagy
apoptotic process
negative regulation of cell proliferation
proteasomal protein catabolic process
protein ubiquitination
negative regulation of cell migration
regulation of MAPK cascade
regulation of lymphocyte differentiation
regulation of myeloid cell differentiation
positive regulation of protein catabolic process
protein autoubiquitination
regulation of protein kinase B signaling
extrinsic apoptotic signaling pathway
negative regulation of macromitophagy
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of gene expression
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of establishment of cell polarity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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