(-)-S-Trityl-D-cysteine is used in medicine as intermediate. It inhibits the human mitotic kinesin Eg5.
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Applications
(-)-S-Trityl-D-cysteine is used in medicine as intermediate. It inhibits the human mitotic kinesin Eg5.
Solubility
Sparingly soluble in water 0.022 g/L 25°C.
Notes
Store in a cool, dry place, in a well sealed container. Store away from oxidizing agents, heat.
RUO – Research Use Only
General References:
- Salvatore DeBonis; Dimitrios A. Skoufias; Rose-Laure Indorato; François Liger; Bernard Marquet; Christian Laggner; Benoît Joseph and Frank Kozielski. Structure-Activity Relationship of S-Trityl-l-Cysteine Analogues as Inhibitors of the Human Mitotic Kinesin Eg5. J. Med. Chem. 2008, 51 (5), 1115-1125.
- Dimitrios A. Skoufias; Salvatore DeBonis; Yasmina Saoudi; Luc Lebeau; Isabelle Crevel; Robert Cross; Richard H. Wade; David Hackney and Frank Kozielski. S-Trityl-L-cysteine Is a Reversible, Tight Binding Inhibitor of the Human Kinesin Eg5 That Specifically Blocks Mitotic Progression. The Journal of Biological Chemistry. 1989, 281, 17559-17569.