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Thermo Scientific Chemicals
5-Azacytidine, 98%
Causes DNA demethylation or hemi-demethylation; a powerful mutagen | CAS: 320-67-2 | C8H12N4O5 | 244.21 g/mol
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Catalog number J64159.06
also known as J64159-06
Price (USD)
275.65
Online Exclusive
306.00Save 30.35 (10%)
Each
Quantity:
5 g
Price (USD)
275.65
Online Exclusive
306.00Save 30.35 (10%)
Each
Chemical Identifiers
CAS320-67-2
IUPAC Name4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
Molecular FormulaC8H12N4O5
InChI KeyNMUSYJAQQFHJEW-KVTDHHQDSA-N
SMILESNC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
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Specifications
Specification Sheet
Specification SheetAssay from Suppliers CofA≥97.5%
Appearance (Color)White to off-white
FormPowder or crystals or crystalline powder
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Solubility
Soluble in water.
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Solubility
Soluble in water.
Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.
WARNING: Cancer – www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- Siva P. Kumpatla.; Timothy C. Hall. Longevity of 5-azacytidine-mediated gene expression and re-establishment of silencing in transgenic rice. Plant Molecular Biology. 1998, 38, (6), 1113-1122.
- Sunil Rangappa.; Chen Fen.; Eng Hin Lee.; Ariff Bongso.; Eugene Sim Kwang Wei. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. The Annals of Thoracic Surgery. 2003, 75, (3), 775-779.