2'-Fluoro-2'-deoxyadenosine, 99%, Thermo Scientific Chemicals

Catalog Number	Quantity
J65441.03 also known as J65441-03	1 g

Catalog number J65441.03

also known as J65441-03

Price (USD)

129.65

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144.00

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Price (USD)

129.65

Online Exclusive

144.00

Save 14.35 (10%)

Chemical Identifiers

CAS64183-27-3

IUPAC Name(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

Molecular FormulaC10H12FN5O3

InChI KeyZGYYPTJWJBEXBC-GPGUAWMRNA-N

SMILESNC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3F)C2=NC=N1

Specifications

Appearance (Color)White to off-white

FormPowder

Assay (HPLC)98.5% min.

Water Content (Karl Fischer Titration)8.0% max.

Solution Test10mg/ml in 1M NaOH: clear, colorless solution

2'-Fluoro-2'-deoxyadenosine is a potential prodrug for 2-fluroadenine, involves deoxygenation by reduction of the 2'-thiocar-bonylimidazolide with (Tms)3SiH as hydrogen donor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2′-Fluoro-2′-deoxyadenosine is a potential prodrug for 2-fluroadenine, involves deoxygenation by reduction of the 2′-thiocar-bonylimidazolide with (Tms)3SiH as hydrogen donor.

Solubility
Soluble in water.

Notes
Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

RUO – Research Use Only

General References:

John Montgomery.; Kathleen Hewson. Nucleosides of 2-Fluoroadenine. J. Med. Chem. 1969, 12, (3), 498-504.
Ranganathan, R. Modification of the 2'-position of purine nucleosides: syntheses of 2'-α-substituted-2'-deoxyadenosine analogs. Tetrahedron Letters. 1977, 18, (15), 1291-1294.