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          • Primary Antibodies ›
          • Endothelin 1 Antibodies

          Invitrogen

          Endothelin 1 Monoclonal Antibody (ENDO20-2101.70)

          1 Published Figure
          1 Reference
          View all (15) Endothelin 1 antibodies

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          Cite Endothelin 1 Monoclonal Antibody (ENDO20-2101.70)

          Additional Information:
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          • Published Figures (1)
          Endothelin 1 Antibody in Neutralization (Neu)
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          Endothelin 1 Antibody in Neutralization (Neu)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Endothelin 1 Antibody (MA1-10818) in Neu

          BMC cancer 2020 - Fig. 3 Breast cancer conditioned medium induces hypertrophy in human cardiomyocytes through endothlin-1 signaling pathway. a Representative images of cardiomyocytes stained with WGA (green) and DAPI (blue), scale bar = 50 mum, b Quantification of cell surface area in cardiomyocytes treated with either regular serum free medium or breast cancer MCF7 CM with or without the antibody against ET-1 (n = 70 per gr... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Endothelin 1 Antibody in Neutralization (Neu)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Product Details

          MA1-10818

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (IHC)

          5-20 µg/mL
          -

          ELISA (ELISA)

          5-20 µg/mL
          -

          Neutralization (Neu)

          -
          View 1 publication 1 publication

          Radioimmune Assays (RIA)

          1-10 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Published species

          Human

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          ENDO20-2101.70

          Immunogen

          Human endothelin 1.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1.3 mg/mL

          Amount

          100 µg

          Purification

          Protein G

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          -20°C or -80°C if preferred

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_1074213

          Product Specific Information

          MA1-10818 detects Endothelin from human samples.

          MA1-10818 has been successfully used in ELISA, radioimmune assay, and immunohistochemistry applications.

          The MA1-10818 immunogen is Human endothelin 1.

          Target Information

          The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Big endothelin 1; Big ET; Big ET 1; Big ET1; BigET; EDN1; Et; preproendothelin-1; unnamed protein product

          View more View less

          Gene Aliases: ARCND3; ET1; HDLCQ7; PPET1; QME

          View more View less

          UniProt ID: (Human) P05305

          View more View less

          Entrez Gene ID: (Human) 1906

          View more View less

          Function(s)
          receptor binding cytokine activity hormone activity protein binding endothelin A receptor binding endothelin B receptor binding receptor agonist activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade response to hypoxia histamine secretion response to amphetamine heart process glomerular filtration regulation of systemic arterial blood pressure by endothelin cardiac neural crest cell migration involved in outflow tract morphogenesis noradrenergic neuron differentiation transcription from RNA polymerase II promoter cellular calcium ion homeostasis mitochondrion organization cell surface receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling axon guidance regulation of blood pressure positive regulation of cell proliferation response to xenobiotic stimulus response to ozone positive regulation of heart rate gene expression positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression neural crest cell differentiation neural crest cell fate commitment response to activity artery smooth muscle contraction vein smooth muscle contraction regulation of vasoconstriction calcium-mediated signaling signal transduction involved in regulation of gene expression peptide hormone secretion nitric oxide transport negative regulation of blood coagulation positive regulation of cell migration neutrophil chemotaxis thyroid gland development neuron projection development positive regulation of prostaglandin biosynthetic process positive regulation of prostaglandin secretion response to lipopolysaccharide response to testosterone negative regulation of smooth muscle cell apoptotic process response to prostaglandin F embryonic heart tube development response to nicotine intracellular signal transduction response to muscle stretch epithelial fluid transport vasoconstriction positive regulation of odontogenesis superoxide anion generation response to amino acid positive regulation of MAPK cascade protein kinase B signaling response to leptin cellular response to human chorionic gonadotropin stimulus leukocyte activation positive regulation of nitric oxide biosynthetic process positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of JNK cascade positive regulation of hormone secretion negative regulation of hormone secretion positive regulation of smooth muscle cell proliferation axon extension positive regulation of calcium-mediated signaling negative regulation of protein metabolic process membrane depolarization canonical Wnt signaling pathway maternal process involved in parturition positive regulation of sarcomere organization axonogenesis involved in innervation positive regulation of cell growth involved in cardiac muscle cell development pharyngeal arch artery morphogenesis positive regulation of chemokine-mediated signaling pathway renal sodium ion absorption cellular response to hydrogen peroxide ERK1 and ERK2 cascade calcium ion transmembrane transport cellular response to calcium ion cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to mineralocorticoid stimulus cellular response to fatty acid cellular response to hypoxia cellular response to xenobiotic stimulus semaphorin-plexin signaling pathway response to dexamethasone response to transforming growth factor beta cellular response to transforming growth factor beta stimulus glomerular endothelium development glomerular visceral epithelial cell differentiation endothelin receptor signaling pathway positive regulation of neutrophil chemotaxis cellular response to toxic substance sympathetic neuron axon guidance cAMP/PKA signal transduction negative regulation of phospholipase C/protein kinase C signal transduction positive regulation of protein localization to nucleus positive regulation of NIK/NF-kappaB signaling response to salt meiotic cell cycle process involved in oocyte maturation positive regulation of vascular smooth muscle cell proliferation positive regulation of artery morphogenesis
          It has to be done as per old AB suggested Products section.

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