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Invitrogen

CD4/CD26 Antibody Cocktail, FITC, PE

View all (3) CD4/CD26 antibodies

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Product Details

MA1-12118

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1/IgG2a

Class

Cocktail

Type

Antibody

Clone

7E14, EUG-6

Immunogen

human peripheral blood T lymphocytes

Conjugate

FITC , PE FITC , PE FITC , PE

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.2% carrier protein

Contains

0.08% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1072289

Product Specific Information

This antibody is a monoclonal mixture of FITC-conjugated CD4 (clone 7E14, isotype IgG1) and PE-conjugated CD26 (clone EUG-6, isotype IgG2a).

Target Information

The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. CD26 [also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA) binding protein]. 1 - 3 is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti CD3-induced IL - 2 production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADCP-2; adenosine deaminase complexing protein 2; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); DPP IV; DPP-IV; Gly-Pro naphthylamidase; Post-proline dipeptidyl aminopeptidase IV; T-cell activation antigen CD26; T-cell surface antigen T4/Leu-3; T4 surface glycoprotein precursor; unnamed protein product; Xaa-Pro-dipeptidylaminopeptidase

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Gene Aliases: ADABP; ADCP2; CD26; CD4mut; DPPIV; IMD79; Leu-3; OKT4D; T4; TP103

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UniProt ID: (Human) P01730, (Human) P27487

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Entrez Gene ID: (Human) 920, (Human) 1803

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Function(s)
virus receptor activity transmembrane signaling receptor activity receptor binding extracellular matrix structural constituent protein binding zinc ion binding lipid binding coreceptor activity immunoglobulin binding enzyme binding protein kinase binding MHC class II protein complex binding signaling receptor activity interleukin-16 binding interleukin-16 receptor activity MHC class II protein binding identical protein binding protein homodimerization activity protein tyrosine kinase binding protease binding serine-type endopeptidase activity serine-type peptidase activity dipeptidyl-peptidase activity tripeptidyl-peptidase activity chemorepellent activity
Process(es)
response to hypoxia proteolysis positive regulation of cell proliferation negative regulation of extracellular matrix disassembly peptide hormone processing receptor-mediated endocytosis of virus by host cell T cell costimulation regulation of cell-cell adhesion mediated by integrin T cell activation endothelial cell migration viral entry into host cell receptor-mediated virion attachment to host cell negative chemotaxis membrane fusion negative regulation of neutrophil chemotaxis glucagon processing positive regulation of immune system process immune response cell adhesion signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol T cell differentiation macrophage differentiation leukocyte chemotaxis response to estradiol maintenance of protein location in cell positive regulation of interleukin-2 production response to vitamin D helper T cell enhancement of adaptive immune response interleukin-15-mediated signaling pathway positive regulation of T cell proliferation T cell selection response to ethanol positive regulation of monocyte differentiation positive regulation of inflammatory response T cell receptor signaling pathway regulation of T cell activation positive regulation of multicellular organismal process cellular response to granulocyte macrophage colony-stimulating factor stimulus response to methamphetamine hydrochloride cellular response to ionomycin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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