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Invitrogen
CD8/CD28 Antibody Cocktail, FITC, PE
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Product Details
MA1-12166
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Cocktail
Type
Antibody
Clone
17D8, B-23
Immunogen
human peripheral blood T lymphocytes and HPB-ALL T-cell line
Conjugate
FITC , PE
FITC , PE
FITC , PE
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.2% carrier protein
Contains
0.08% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).
Target Information
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a molecule; CD8alpha; CD8b molecule; CD8beta; cell surface glycoprotein T8 precursor; Leu-2; Leu2 T-lymphocyte antigen; Ly-3 homolog; MGC138290; OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein (CD8-beta) precursor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell differentiation antigen Leu-2/T8; T-cell-specific homodimer surface protein precursor; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen; unnamed protein product
Gene Aliases: CD8; CD8alpha; CD8B1; CD8beta; IMD116; IMD123; LEU2; Ly-3; LY3; LYT3; p32; P37; Tp44
UniProt ID: (Human) P10747, (Human) P01732, (Human) P10966
Entrez Gene ID: (Human) 940, (Human) 925, (Human) 926
adaptive immune response
immune response
transmembrane receptor protein tyrosine kinase signaling pathway
T cell activation
regulation of immune response
T cell receptor signaling pathway
T cell mediated immunity
cell surface receptor signaling pathway
antigen processing and presentation
cytotoxic T cell differentiation
positive regulation of cytokine production
immune system process
humoral immune response
positive regulation of gene expression
negative regulation of gene expression
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-2 production
positive regulation of interleukin-4 production
positive regulation of T cell proliferation
regulation of T cell proliferation
negative regulation of apoptotic process
regulatory T cell differentiation
positive regulation of viral genome replication
positive regulation of translation
positive regulation of mitotic nuclear division
positive regulation of T cell receptor signaling pathway
positive regulation of T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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