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Invitrogen

LEF1 (Alternate Exon) Monoclonal Antibody (1C3)

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LEF1 (Alternate Exon) Monoclonal Antibody (1C3)

Product Details

MA1-12487

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1C3

Immunogen

Recombinant full-length LEF-1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS

Contains

0.08% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1076478

Target Information

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp586H0919; FLJ46390; HGNC:6551; hLEF-1 isoform; hLEF-1(8A); HMG Binding Domain; HMG box transcription factor; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha; unnamed protein product

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Gene Aliases: ECTD1; ECTD17; LEF-1; TCF10; TCF1ALPHA; TCF7L3

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UniProt ID: (Human) Q9UJU2

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Entrez Gene ID: (Human) 51176

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding DNA binding, bending estrogen receptor binding histone deacetylase binding sequence-specific DNA binding gamma-catenin binding armadillo repeat domain binding C2H2 zinc finger domain binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition regulation of transcription from RNA polymerase II promoter positive regulation of gene expression positive regulation of epithelial to mesenchymal transition Wnt signaling pathway cell differentiation neutrophil differentiation positive regulation of cell migration positive regulation of granulocyte differentiation negative regulation of interleukin-13 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production negative regulation of apoptotic process negative regulation of DNA binding positive regulation by host of viral transcription T-helper 1 cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurogenesis canonical Wnt signaling pathway cell chemotaxis secondary palate development protein localization to chromatin cellular response to cytokine stimulus cellular response to interleukin-4 positive regulation of cell proliferation in bone marrow negative regulation of apoptotic process in bone marrow positive regulation of cell cycle process positive regulation of odontoblast differentiation positive regulation of endothelial cell-matrix adhesion via fibronectin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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