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Invitrogen
Cardiac Troponin T Monoclonal Antibody (1C11cc)
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FIGURE: 1 / 4
Cardiac Troponin T Antibody (MA1-16687) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of iPSC (Lane 1), iPSC differentiated to Cardiomyocytes (Lane 2), tissue extracts (30 µg lysate) of Mouse Heart (Lane 3), Rat Heart (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Skeletal Muscle (Lane 6) and Mouse Brain (Lane 7). The blot was probed with Anti-Cardiac Troponin T Monoclonal Antibody (1C11) (Product # MA1-16687, 1:500 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A281... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-16687
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1C11cc
Immunogen
Free human cTnT.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
5.8 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is useful for Troponin T immunoassay.
This antibody will work best as a capture for BIAcore.
Suggested positive control: antigen standard for TNNT2 (transient overexpression lysate).
Target Information
Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; cardiac muscle troponin T; cardiac TnT; cardiac troponin T; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; cTnT; MGC3889; tnTc; troponin T; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T2; unnamed protein product
Gene Aliases: CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; RATCTTG; RCM3; Tnnt3; Tnt; TnTC
UniProt ID: (Human) P45379, (Rat) P50753, (Mouse) P50752
Entrez Gene ID: (Human) 7139, (Dog) 403532, (Rat) 24837, (Mouse) 21956
regulation of muscle contraction
striated muscle contraction
regulation of heart contraction
muscle filament sliding
negative regulation of ATPase activity
positive regulation of ATPase activity
sarcomere organization
response to calcium ion
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
muscle contraction
heart development
response to bacterium
regulation of muscle filament sliding speed
tissue remodeling
actin crosslink formation
atrial cardiac muscle tissue morphogenesis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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