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Invitrogen
HIP1R Monoclonal Antibody (1E1)
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FIGURE: 1 / 2
HIP1R Antibody (MA1-16750) in IHC (P)
Immunohistochemistry analysis of HIP1R in FFPE tissue section of human kidney. Samples were incubated with HIP1R monoclonal antibody (Product # MA1-16750) using a dilution of 1:200. The staining was developed using HRP labeled anti-rabbit secondary antibody and DAB reagent, and nuclei of cells were counter-stained with hematoxylin. This HIP1 related antibody generated strong staining of the cytoplasm and me... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-16750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bacteria,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1E1
Immunogen
Human HIP1 Related-TALIN Homology Region (57 kDa).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: HeLa whole cell lysate and rat brain homogenate, Hela whole cell lysate, antigen standard for IFT57 (transient overexpression lysate), rat brain protein.
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-binding protein; HIP-12; HIP1-related protein; huntingtin interacting protein 12; unnamed protein product
Gene Aliases: HIP12; HIP3; ILWEQ; mKIAA0655
UniProt ID: (Human) O75146, (Mouse) Q9JKY5
Entrez Gene ID: (Human) 9026, (Mouse) 29816, (Rat) 81917
actin binding
protein binding
phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
SH3 domain binding
clathrin binding
clathrin light chain binding
phosphatidylinositol binding
clathrin adaptor activity
identical protein binding
protein homodimerization activity
phosphatidylinositol-3,4-bisphosphate binding
protein heterodimerization activity
actin filament binding
phosphatidylinositol-3,5-bisphosphate binding
endocytosis
receptor-mediated endocytosis
actin filament organization
regulation of endocytosis
negative regulation of actin filament polymerization
regulation of actin cytoskeleton organization
negative regulation of Arp2/3 complex-mediated actin nucleation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
clathrin coat assembly
protein stabilization
positive regulation of transport
positive regulation of cellular component organization
digestive system development
regulation of gastric acid secretion
membrane organization
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
postsynapse organization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of clathrin coat assembly
regulation of clathrin-mediated endocytosis
positive regulation of platelet-derived growth factor receptor-beta signaling pathway
positive regulation of clathrin-mediated endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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