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Invitrogen
Collagen III Monoclonal Antibody (FH-7A)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-22147
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rabbit,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
FH-7A
Immunogen
Human collagen type III.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
4 mg/mL
Amount
400 µg
Storage buffer
Ascites
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: human skin.
MA1-22147 specifically recognizes native and denatured collagen type III in human and rat samples. It does not recognize collagen types I, II, IV, V, VI and X.
By Western blot, this antibody detects a ~70 kDa band in reduced denatured samples, and a ~300 kDa band in non-reduced, non-denatured samples.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I Collagen. Mutations in th gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations; these mutations alter splicing, often leading to the exclusion of multiple exons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha-1 type III collagen; alpha-1(III) procollagen; alpha1 (III) collagen; COL 3; COL3; COL3 alpha 1; Collagen 3; collagen, fetal; collagen, type III, alpha 1; Collagen3; Ehlers-Danlos syndrome type IV, autosomal dominant; FLJ34534; MGC93704; pro alpha 1 type III collagen; procollagen, type III, alpha 1; unnamed protein product
Gene Aliases: EDS4A; EDSVASC; PMGEDSV
UniProt ID: (Human) P02461, (Rat) P13941
Entrez Gene ID: (Human) 1281, (Rabbit) 100009177, (Rat) 84032
in utero embryonic development
neuron migration
tissue homeostasis
chondrocyte differentiation
cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
heart development
response to radiation
response to wounding
gene expression
peptide cross-linking
layer formation in cerebral cortex
cerebral cortex development
platelet activation
extracellular matrix organization
collagen fibril organization
lung development
transforming growth factor beta1 production
response to cytokine
positive regulation of Rho protein signal transduction
multicellular organism growth
aorta development
limb joint morphogenesis
wound healing
skin development
fibroblast proliferation
elastic fiber assembly
animal organ development
skeletal system morphogenesis
system development
negative regulation of immune response
cartilage development
endochondral bone morphogenesis
aorta smooth muscle tissue morphogenesis
basement membrane organization
fibril organization
response to angiotensin
negative regulation of neuron migration
skeletal system development
blood vessel development
response to mechanical stimulus
digestive tract development
cellular response to amino acid stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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