Search
Invitrogen
HPV Type 16/18 E7 Monoclonal Antibody (718-15)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA1-23076
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
718-15
Immunogen
HPV oncoprotein E7, type 18.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
6.2 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-23076 detects HPV-18 E7 in virus samples.
Target Information
The E7 gene from Human Papillomavirus Types 16 and 18 plays a crucial role in the pathogenesis of HPV-related cervical and head and neck cancers. HPV16 and HPV18 are responsible for about 70% of these cancers. The E7 protein is particularly significant due to its interactions with the retinoblastoma protein (pRB), where it disrupts pRB's function to promote uncontrolled cell division. This interaction is facilitated by an ordered Zinc finger motif within the E7 protein. Structurally, E7 comprises disordered N-terminal regions and structured C-terminal regions, which are critical for its role in cellular transformation and oncogenic progression. This structural composition is conserved across different HPV types, indicating its evolutionary importance in maintaining E7's function. Specifically, the 98 amino acids of HPV16 E7 are highly conserved, emphasizing their importance in carcinogenesis. Furthermore, E7, along with E6, activates pathways that result in the inactivation of pRB, which is a pivotal step in the development of cervical cancer. HPV infections typically resolve spontaneously, but persistent infections with high-risk types like HPV16 and 18 increase the risk of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support